Polymer-caged lipsomes: A pH-responsive delivery system with high stability

Sang Min Lee, Haimei Chen, Christine M. Dettmer, Thomas V. O'Halloran*, Sonbinh T. Nguyen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

187 Scopus citations

Abstract

Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2′-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.

Original languageEnglish (US)
Pages (from-to)15096-15097
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number49
DOIs
StatePublished - Dec 12 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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