Abstract
In this paper, we describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be cross-linked. After UV-induced thiol-ene crosslinking, the core of the PFC emulsion remains in liquid form even at temperatures exceeding their boiling points. Critically, the formulation permits vaporization at rarefactional pressures relevant for clinical ultrasound.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15-18 |
| Number of pages | 4 |
| Journal | Journal of the American Chemical Society |
| Volume | 139 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 11 2017 |
Funding
The authors acknowledge support of this work by the Army Research Office (W91 INF-14-1-0169 and W911NF-15-1-0568). A.M.V. was supported by the NCI R25T institutional training grant 1R25CA153915-01 (Cancer Researchers in Nanotechnology (CRIN)) and T32 training grant NIH-NIBIB-T32-5T32EB005970 (Training Clinical Scientists in Radiological Imaging).
ASJC Scopus subject areas
- General Chemistry
- Biochemistry
- Catalysis
- Colloid and Surface Chemistry