TY - JOUR
T1 - Polymer-stabilized perfluorobutane nanodroplets for ultrasound imaging agents
AU - Huang, Yuran
AU - Vezeridis, Alexander M.
AU - Wang, James
AU - Wang, Zhao
AU - Thompson, Matthew
AU - Mattrey, Robert F.
AU - Gianneschi, Nathan C.
N1 - Funding Information:
The authors acknowledge support of this work by the Army Research Office (W91 INF-14-1-0169 and W911NF-15-1-0568). A.M.V. was supported by the NCI R25T institutional training grant 1R25CA153915-01 (Cancer Researchers in Nanotechnology (CRIN)) and T32 training grant NIH-NIBIB-T32-5T32EB005970 (Training Clinical Scientists in Radiological Imaging).
Publisher Copyright:
© 2016 American Chemical Society.
PY - 2017/1/11
Y1 - 2017/1/11
N2 - In this paper, we describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be cross-linked. After UV-induced thiol-ene crosslinking, the core of the PFC emulsion remains in liquid form even at temperatures exceeding their boiling points. Critically, the formulation permits vaporization at rarefactional pressures relevant for clinical ultrasound.
AB - In this paper, we describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be cross-linked. After UV-induced thiol-ene crosslinking, the core of the PFC emulsion remains in liquid form even at temperatures exceeding their boiling points. Critically, the formulation permits vaporization at rarefactional pressures relevant for clinical ultrasound.
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U2 - 10.1021/jacs.6b08800
DO - 10.1021/jacs.6b08800
M3 - Article
C2 - 28032757
AN - SCOPUS:85019054684
VL - 139
SP - 15
EP - 18
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 1
ER -