Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

Lyndsay M. Randolph, Clare L.M. Leguyader, Michael E. Hahn*, Christopher M. Andolina, Joseph P. Patterson, Robert F. Mattrey, Jill E. Millstone, Mauro Botta, Miriam Scadeng, Nathan C. Gianneschi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A Gd3+-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

Original languageEnglish (US)
Pages (from-to)4230-4236
Number of pages7
JournalChemical Science
Volume7
Issue number7
DOIs
StatePublished - 2016

Funding

We acknowledge support from the NIH through a Director's New Innovator Award (1DP2OD008724), through the NIBIB (1R01EB011633) and for a Transformative Award (NHLBI R01HL117326). C. L. M. L. is supported by a training grant from the Department of Education (P200A12022314). M. E. H. supported by a training grant from the NIH (5T32EB005970). N. C. G. acknowledges the Alfred P. Sloan Foundation for a fellowship. We acknowledge the use of the UCSD Cryo-Electron Microscopy Facility which is supported by NIH grants to Dr Timothy S. Baker and a gift from the Agouron Institute to UCSD. We acknowledge the UCSD Chemistry and Biochemistry Molecular MS Facility for mass analysis of compounds.

ASJC Scopus subject areas

  • General Chemistry

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