@article{afc846d4276644c59ddbf4b76de41f69,
title = "Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents",
abstract = "A Gd3+-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.",
author = "Randolph, {Lyndsay M.} and Leguyader, {Clare L.M.} and Hahn, {Michael E.} and Andolina, {Christopher M.} and Patterson, {Joseph P.} and Mattrey, {Robert F.} and Millstone, {Jill E.} and Mauro Botta and Miriam Scadeng and Gianneschi, {Nathan C.}",
note = "Funding Information: We acknowledge support from the NIH through a Director's New Innovator Award (1DP2OD008724), through the NIBIB (1R01EB011633) and for a Transformative Award (NHLBI R01HL117326). C. L. M. L. is supported by a training grant from the Department of Education (P200A12022314). M. E. H. supported by a training grant from the NIH (5T32EB005970). N. C. G. acknowledges the Alfred P. Sloan Foundation for a fellowship. We acknowledge the use of the UCSD Cryo-Electron Microscopy Facility which is supported by NIH grants to Dr Timothy S. Baker and a gift from the Agouron Institute to UCSD. We acknowledge the UCSD Chemistry and Biochemistry Molecular MS Facility for mass analysis of compounds. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",
year = "2016",
doi = "10.1039/c6sc00342g",
language = "English (US)",
volume = "7",
pages = "4230--4236",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "7",
}