Polymerization of a peptide-based enzyme substrate

Michael E. Hahn; Lyndsay M. Randolph; Lisa Adamiak; Matthew P. Thompson; Nathan C. Gianneschi

doi:10.1039/c3cc40472b

Polymerization of a peptide-based enzyme substrate

Michael E. Hahn, Lyndsay M. Randolph, Lisa Adamiak, Matthew P. Thompson, Nathan C. Gianneschi^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates.

Original language	English (US)
Pages (from-to)	2873-2875
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	28
DOIs	https://doi.org/10.1039/c3cc40472b
State	Published - Mar 12 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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AU - Hahn, Michael E.

AU - Randolph, Lyndsay M.

AU - Adamiak, Lisa

AU - Thompson, Matthew P.

AU - Gianneschi, Nathan C.

PY - 2013/3/12

Y1 - 2013/3/12

N2 - Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates.

AB - Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates.

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Polymerization of a peptide-based enzyme substrate

Abstract

ASJC Scopus subject areas

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