Polymers and proteins: Interactions at interfaces

Igal Szleifer

doi:10.1016/S1359-0286(97)80125-8

Polymers and proteins: Interactions at interfaces

Igal Szleifer^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

184 Scopus citations

Abstract

The ability of polymer molecules attached at one end to a surface to prevent or enhance protein adsorption has been studied experimentally and theoretically. Recent systematic studies show that surface density seems to be the most important property of the tethered layer that determines its ability to prevent protein adsorption. Theoretical studies predict that the interactions of the polymer layer with the proteins and the adsorption behavior do not depend in the same way on polymer molecular weight and on the type of interaction of the polymer with the surface.

Original language	English (US)
Pages (from-to)	337-344
Number of pages	8
Journal	Current Opinion in Solid State and Materials Science
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/S1359-0286(97)80125-8
State	Published - 1997

Funding

This work is supported by the National Science Foundation, grant CTS- 9624268. The author is a Camille Dreyfus Teacher-Scholar.

Keywords

EO ethylene oxide
PEG polyethylene glycol
PEO polyethylene oxide
PS polystyrene
SCMF single-chain mean-field

ASJC Scopus subject areas

General Materials Science

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10.1016/S1359-0286(97)80125-8

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title = "Polymers and proteins: Interactions at interfaces",

abstract = "The ability of polymer molecules attached at one end to a surface to prevent or enhance protein adsorption has been studied experimentally and theoretically. Recent systematic studies show that surface density seems to be the most important property of the tethered layer that determines its ability to prevent protein adsorption. Theoretical studies predict that the interactions of the polymer layer with the proteins and the adsorption behavior do not depend in the same way on polymer molecular weight and on the type of interaction of the polymer with the surface.",

keywords = "EO ethylene oxide, PEG polyethylene glycol, PEO polyethylene oxide, PS polystyrene, SCMF single-chain mean-field",

author = "Igal Szleifer",

note = "Funding Information: This work is supported by the National Science Foundation, grant CTS- 9624268. The author is a Camille Dreyfus Teacher-Scholar.",

year = "1997",

doi = "10.1016/S1359-0286(97)80125-8",

language = "English (US)",

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TY - JOUR

T1 - Polymers and proteins

T2 - Interactions at interfaces

AU - Szleifer, Igal

N1 - Funding Information: This work is supported by the National Science Foundation, grant CTS- 9624268. The author is a Camille Dreyfus Teacher-Scholar.

PY - 1997

Y1 - 1997

N2 - The ability of polymer molecules attached at one end to a surface to prevent or enhance protein adsorption has been studied experimentally and theoretically. Recent systematic studies show that surface density seems to be the most important property of the tethered layer that determines its ability to prevent protein adsorption. Theoretical studies predict that the interactions of the polymer layer with the proteins and the adsorption behavior do not depend in the same way on polymer molecular weight and on the type of interaction of the polymer with the surface.

AB - The ability of polymer molecules attached at one end to a surface to prevent or enhance protein adsorption has been studied experimentally and theoretically. Recent systematic studies show that surface density seems to be the most important property of the tethered layer that determines its ability to prevent protein adsorption. Theoretical studies predict that the interactions of the polymer layer with the proteins and the adsorption behavior do not depend in the same way on polymer molecular weight and on the type of interaction of the polymer with the surface.

KW - EO ethylene oxide

KW - PEG polyethylene glycol

KW - PEO polyethylene oxide

KW - PS polystyrene

KW - SCMF single-chain mean-field

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DO - 10.1016/S1359-0286(97)80125-8

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VL - 2

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EP - 344

JO - Current Opinion in Solid State and Materials Science

JF - Current Opinion in Solid State and Materials Science

IS - 3

ER -

Polymers and proteins: Interactions at interfaces

Abstract

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Keywords

ASJC Scopus subject areas

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