Polymorphisms in adenosine receptor genes are associated with infarct size in patients with ischemic cardiomyopathy

Z. Tang, M. A. Diamond, J. M. Chen, T. A. Holly, R. O. Bonow, A. Dasgupta, T. Hyslop, A. Purzycki, J. Wagner, D. M. McNamara, T. Kukulski, S. Wos, E. J. Velazquez, K. Ardlie, A. M. Feldman*

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The goal of this experiment was to identify the presence of genetic variants in the adenosine receptor genes and assess their relationship to infarct size in a population of patients with ischemic cardiomyopathy. Adenosine receptors play an important role in protecting the heart during ischemia and in mediating the effects of ischemic preconditioning. We sequenced DNA samples from 273 individuals with ischemic cardiomyopathy and from 203 normal controls to identify the presence of genetic variants in the adenosine receptor genes. Subsequently, we analyzed the relationship between the identified genetic variants and infarct size, left ventricular size, and left ventricular function. Three variants in the 3′-untranslated region of the A1- adenosine gene (nt 1689 C/A, nt 2206 Tdel, nt 2683del36) and an informative polymorphism in the coding region of the A3-adenosine gene (nt 1509 A/C I248L) were associated with changes in infarct size. These results suggest that genetic variants in the adenosine receptor genes may predict the heart's response to ischemia or injury and might also influence an individual's response to adenosine therapy.

Original languageEnglish (US)
Pages (from-to)435-440
Number of pages6
JournalClinical pharmacology and therapeutics
Volume82
Issue number4
DOIs
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Tang, Z., Diamond, M. A., Chen, J. M., Holly, T. A., Bonow, R. O., Dasgupta, A., Hyslop, T., Purzycki, A., Wagner, J., McNamara, D. M., Kukulski, T., Wos, S., Velazquez, E. J., Ardlie, K., & Feldman, A. M. (2007). Polymorphisms in adenosine receptor genes are associated with infarct size in patients with ischemic cardiomyopathy. Clinical pharmacology and therapeutics, 82(4), 435-440. https://doi.org/10.1038/sj.clpt.6100331