Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells

Michael I. Zimmer, Hanh P. Nguyen, Bin Wang, Honglin Xu, Angela Colmone, Kyrie Felio, Hak Jong Choi, Ping Zhou, Maria Luisa Alegre, Chyung Ru Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity. Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains. We demonstrate that polymorphisms in CD1d affect the presentation of endogenous and exogenous ligands to CD1d-restricted T cells, including type I (Vα14i) and type II (non-Vα14i) natural killer T (NKT) cells. Using congenic mice, we found CD1d polymorphisms affect the thymic selection of type I NKT cells and induce allogeneic T cell responses. Collectively, results from these studies demonstrate a role for polymorphisms in influencing the development and function of CD1d-restricted T cells.

Original languageEnglish (US)
Pages (from-to)1909-1914
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue number6
DOIs
StatePublished - Feb 10 2009

Keywords

  • T cell activation
  • T cell development

ASJC Scopus subject areas

  • General

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