Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: An update and meta-analysis

Michelle N. Sicard, Clement C. Zai, Arun K. Tiwari, Renan P. Souza, Herbert Y. Meltzer, Jeffrey A. Lieberman, James L. Kennedy, Daniel J. Müller

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Aims: This study aims to test for possible associations between the gene coding for the 5-HT2C receptor and antipsychotic-induced weight gain. Materials & methods: Four HTR2C polymorphisms (rs498207, C-759T, G-697C and Ser23Cys) were investigated in our sample of 205 chronic schizophrenia patients. Results: Significant over-representation of the C-G-Cys23 haplotype in patients with weight gain (OR: 1.93; 95% CI: 1.04-3.56; p = 0.0015) was found. Similarly, haplotype analyses of percentage weight change were also significant (p = 0.029) for the C-G-Cys23 haplotype associated with the highest average percent weight gain. Observations in the polymorphisms are consistent with previous studies. An updated meta-analysis of nine previous studies plus our current sample suggest that the -759C allele is associated with antipsychotic-induced weight gain. Conclusion: Additional studies, including the resequencing of the region surrounding the HTR2C promoter, and functional studies of the promoter polymorphisms, may elucidate the mechanism underlying this genetic association.

Original languageEnglish (US)
Pages (from-to)1561-1571
Number of pages11
JournalPharmacogenomics
Volume11
Issue number11
DOIs
StatePublished - Nov 2010

Keywords

  • 5-HT2C receptor
  • HTR2C
  • antipsychotics
  • genetics
  • meta-analysis
  • weight gain

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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