Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels

Christopher S. Carlson*, Shelley Force Aldred, Philip K. Lee, Russell P. Tracy, Stephen M. Schwartz, Mark Rieder, Kiang Liu, O. Dale Williams, Carlos Iribarren, E. Cora Lewis, Myriam Fornage, Eric Boerwinkle, Myron Gross, Cashell Jaquish, Deborah A. Nickerson, Richard M. Myers, David S. Siscovick, Alexander P. Reiner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

279 Scopus citations


Elevated plasma levels of C-reactive protein (CRP), an inflammation- sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.

Original languageEnglish (US)
Pages (from-to)64-77
Number of pages14
JournalAmerican journal of human genetics
Issue number1
StatePublished - Jul 2005

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics


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