TY - JOUR
T1 - Polymorphonuclear leukocyte adherence to nylon
T2 - effect of oral corticosteroids.
AU - McGillen, J.
AU - Phair, J.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 1979/11
Y1 - 1979/11
N2 - The effect of orally administered glucocorticoids on polymorphonuclear leukocyte adherence was studied by using the nylon fiber adherence assay. Inhibition of adherence 4 h after administration of the agent was confirmed, and in addition, augmentation of adherence was noted 24 h after ingestion of prednisone. Crossover studies revealed inhibition and augmentation to be cell associated as well as plasma mediated. Suspension of washed, dextran-sedimented polymorphonuclear leukocytes, harvested 4 h after prednisone ingestion in base-line or 24-h plasma failed to reverse inhibition of adherence. Adherence of 24-h polymorphonuclear leukocytes was augmented when suspended in all test plasmas. Plasma-mediated effects were demonstrated by inhibition of base-line adherence of polymorphonuclear leukocytes suspended in 4-h plasma and augmentation of adherence of cells in 24-h plasma. Plasma-mediated effects were reversible by washing.
AB - The effect of orally administered glucocorticoids on polymorphonuclear leukocyte adherence was studied by using the nylon fiber adherence assay. Inhibition of adherence 4 h after administration of the agent was confirmed, and in addition, augmentation of adherence was noted 24 h after ingestion of prednisone. Crossover studies revealed inhibition and augmentation to be cell associated as well as plasma mediated. Suspension of washed, dextran-sedimented polymorphonuclear leukocytes, harvested 4 h after prednisone ingestion in base-line or 24-h plasma failed to reverse inhibition of adherence. Adherence of 24-h polymorphonuclear leukocytes was augmented when suspended in all test plasmas. Plasma-mediated effects were demonstrated by inhibition of base-line adherence of polymorphonuclear leukocytes suspended in 4-h plasma and augmentation of adherence of cells in 24-h plasma. Plasma-mediated effects were reversible by washing.
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U2 - 10.1128/iai.26.2.542-546.1979
DO - 10.1128/iai.26.2.542-546.1979
M3 - Article
C2 - 546786
AN - SCOPUS:0018536309
SN - 0019-9567
VL - 26
SP - 542
EP - 546
JO - Infection and immunity
JF - Infection and immunity
IS - 2
ER -
