Poly(N-isopropylacrylamide)-based semi-interpenetrating polymer networks for tissue engineering applications. Effects of linear poly(acrylic acid) chains on rheology

Ranee A. Stile, Eugene Chung, Wesley R. Burghardt, Kevin E. Healy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Semi-interpenetrating polymer networks (semi-IPNs), comprised of poly(N-isopropyl-acrylamide-co-acrylic acid) (p(NIPAAm-co-AAc)) hydrogels and linear p(AAc) chains, were synthesized, and the effects of the p(AAc) chains on semi-IPN rheology were examined. Oscillatory shear rheometry studies were performed and the theological data were analyzed as a function of temperature, frequency, and p(AAc) chain amount (weight average molecular weight (Mw) 4.5 × 105 g/mol). At 22°C, the semi-IPNs, as well as control p(NIPAAm-co-AAc) hydrogels, demonstrated rheological data that were representative of soft, loosely cross-linked solids. Furthermore, only the highest p(AAc) chain amount tested affected the rigidity of the p(NIPAAm-co-AAc)-based semi-IPNs, as compared to the p(NIPAAm-co-AAc) hydrogels. At 37°C, the complex shear moduli (G*) demonstrated by the p(NEPAAm-co-AAc -based semi-IPNs were significantly greater than G* exhibited by the p(NIPAAm-co-AAc) hydrogels, and the semi-IPN G* values significantly increased with increasing p(AAc) chain amount. These results can be used to develop p(NIPAAm)-based semi-IPNs with tailored mechanical properties that may function as scaffolds in tissue engineering initiatives.

Original languageEnglish (US)
Pages (from-to)865-878
Number of pages14
JournalJournal of Biomaterials Science, Polymer Edition
Volume15
Issue number7
DOIs
StatePublished - 2004

Keywords

  • Acrylic acid
  • N-isopropylacrylamide
  • Oscillatory shear rheometry
  • Rheology
  • Semi-IPN

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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