Poly(oligonucleotide)

Carrie R. James; Anthony M. Rush; Thomas Insley; Lela Vuković; Lisa Adamiak; Petr Král; Nathan C. Gianneschi

doi:10.1021/ja503142s

Poly(oligonucleotide)

Carrie R. James, Anthony M. Rush, Thomas Insley, Lela Vuković, Lisa Adamiak, Petr Král, Nathan C. Gianneschi^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH₂)(C ₅H₅N)₂(Cl)₂RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.

Original language	English (US)
Pages (from-to)	11216-11219
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	136
Issue number	32
DOIs	https://doi.org/10.1021/ja503142s
State	Published - Aug 13 2014

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja503142s

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title = "Poly(oligonucleotide)",

abstract = "Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C 5H5N)2(Cl)2RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.",

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doi = "10.1021/ja503142s",

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T1 - Poly(oligonucleotide)

AU - James, Carrie R.

AU - Rush, Anthony M.

AU - Insley, Thomas

AU - Vuković, Lela

AU - Adamiak, Lisa

AU - Král, Petr

AU - Gianneschi, Nathan C.

PY - 2014/8/13

Y1 - 2014/8/13

N2 - Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C 5H5N)2(Cl)2RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.

AB - Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C 5H5N)2(Cl)2RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.

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DO - 10.1021/ja503142s

M3 - Article

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AN - SCOPUS:84906087932

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SP - 11216

EP - 11219

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 32

ER -

Poly(oligonucleotide)

Abstract

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