Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors

Hui Chen, Cheddhi Thomas, Felipe Andres Munoz, Sanda Alexandrescu, Craig M. Horbinski, Adriana Olar, Declan McGuone, Sandra Camelo-Piragua, Lu Wang, Elena Pentsova, Joanna Phillips, Kenneth Aldape, Wen Chen, A. John Iafrate, Andrew S. Chi, David Zagzag, John G. Golfinos, Dimitris G. Placantonakis, Marc Rosenblum, Pamela Ohman-StricklandMeera Hameed, Matija Snuderl*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. Methods: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS). Results: In our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with <30% polysomic cells. Polysomy had no prognostic significance on PFS or OS in patients with 1p/19q maintenance. Conclusions: The presence of polysomy in oligodendroglial tumors with codeletion of 1p/19q predicts early recurrence and short survival in patients with 1p/19q codeleted tumors.

Original languageEnglish (US)
Pages (from-to)1164-1174
Number of pages11
JournalNeuro-oncology
Volume21
Issue number9
DOIs
StatePublished - Sep 6 2019

Keywords

  • 1p/19q codeletion
  • Glioma
  • Oligodendroglioma
  • Polysomy

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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