Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors

Hui Chen; Cheddhi Thomas; Felipe Andres Munoz; Sanda Alexandrescu; Craig M. Horbinski; Adriana Olar; Declan McGuone; Sandra Camelo-Piragua; Lu Wang; Elena Pentsova; Joanna Phillips; Kenneth Aldape; Wen Chen; A. John Iafrate; Andrew S. Chi; David Zagzag; John G. Golfinos; Dimitris G. Placantonakis; Marc Rosenblum; Pamela Ohman-Strickland; Meera Hameed; Matija Snuderl

doi:10.1093/neuonc/noz098

Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors

Hui Chen, Cheddhi Thomas, Felipe Andres Munoz, Sanda Alexandrescu, Craig M. Horbinski, Adriana Olar, Declan McGuone, Sandra Camelo-Piragua, Lu Wang, Elena Pentsova, Joanna Phillips, Kenneth Aldape, Wen Chen, A. John Iafrate, Andrew S. Chi, David Zagzag, John G. Golfinos, Dimitris G. Placantonakis, Marc Rosenblum, Pamela Ohman-StricklandMeera Hameed, Matija Snuderl^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. Methods: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS). Results: In our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with <30% polysomic cells. Polysomy had no prognostic significance on PFS or OS in patients with 1p/19q maintenance. Conclusions: The presence of polysomy in oligodendroglial tumors with codeletion of 1p/19q predicts early recurrence and short survival in patients with 1p/19q codeleted tumors.

Original language	English (US)
Pages (from-to)	1164-1174
Number of pages	11
Journal	Neuro-oncology
Volume	21
Issue number	9
DOIs	https://doi.org/10.1093/neuonc/noz098
State	Published - Sep 6 2019

Keywords

1p/19q codeletion
Glioma
Oligodendroglioma
Polysomy

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/neuonc/noz098

Cite this

Chen, H., Thomas, C., Munoz, F. A., Alexandrescu, S., Horbinski, C. M., Olar, A., McGuone, D., Camelo-Piragua, S., Wang, L., Pentsova, E., Phillips, J., Aldape, K., Chen, W., Iafrate, A. J., Chi, A. S., Zagzag, D., Golfinos, J. G., Placantonakis, D. G., Rosenblum, M., ... Snuderl, M. (2019). Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors. Neuro-oncology, 21(9), 1164-1174. https://doi.org/10.1093/neuonc/noz098

@article{d43d146fbe1d40a88f821759192c03ab,

title = "Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors",

abstract = "Background: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. Methods: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS). Results: In our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with <30% polysomic cells. Polysomy had no prognostic significance on PFS or OS in patients with 1p/19q maintenance. Conclusions: The presence of polysomy in oligodendroglial tumors with codeletion of 1p/19q predicts early recurrence and short survival in patients with 1p/19q codeleted tumors.",

keywords = "1p/19q codeletion, Glioma, Oligodendroglioma, Polysomy",

author = "Hui Chen and Cheddhi Thomas and Munoz, {Felipe Andres} and Sanda Alexandrescu and Horbinski, {Craig M.} and Adriana Olar and Declan McGuone and Sandra Camelo-Piragua and Lu Wang and Elena Pentsova and Joanna Phillips and Kenneth Aldape and Wen Chen and Iafrate, {A. John} and Chi, {Andrew S.} and David Zagzag and Golfinos, {John G.} and Placantonakis, {Dimitris G.} and Marc Rosenblum and Pamela Ohman-Strickland and Meera Hameed and Matija Snuderl",

year = "2019",

month = sep,

day = "6",

doi = "10.1093/neuonc/noz098",

language = "English (US)",

volume = "21",

pages = "1164--1174",

journal = "Neuro-oncology",

issn = "1522-8517",

publisher = "Oxford University Press",

number = "9",

}

Chen, H, Thomas, C, Munoz, FA, Alexandrescu, S, Horbinski, CM, Olar, A, McGuone, D, Camelo-Piragua, S, Wang, L, Pentsova, E, Phillips, J, Aldape, K, Chen, W, Iafrate, AJ, Chi, AS, Zagzag, D, Golfinos, JG, Placantonakis, DG, Rosenblum, M, Ohman-Strickland, P, Hameed, M & Snuderl, M 2019, 'Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors', Neuro-oncology, vol. 21, no. 9, pp. 1164-1174. https://doi.org/10.1093/neuonc/noz098

TY - JOUR

T1 - Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors

AU - Chen, Hui

AU - Thomas, Cheddhi

AU - Munoz, Felipe Andres

AU - Alexandrescu, Sanda

AU - Horbinski, Craig M.

AU - Olar, Adriana

AU - McGuone, Declan

AU - Camelo-Piragua, Sandra

AU - Wang, Lu

AU - Pentsova, Elena

AU - Phillips, Joanna

AU - Aldape, Kenneth

AU - Chen, Wen

AU - Iafrate, A. John

AU - Chi, Andrew S.

AU - Zagzag, David

AU - Golfinos, John G.

AU - Placantonakis, Dimitris G.

AU - Rosenblum, Marc

AU - Ohman-Strickland, Pamela

AU - Hameed, Meera

AU - Snuderl, Matija

PY - 2019/9/6

Y1 - 2019/9/6

N2 - Background: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. Methods: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS). Results: In our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with <30% polysomic cells. Polysomy had no prognostic significance on PFS or OS in patients with 1p/19q maintenance. Conclusions: The presence of polysomy in oligodendroglial tumors with codeletion of 1p/19q predicts early recurrence and short survival in patients with 1p/19q codeleted tumors.

AB - Background: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. Methods: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS). Results: In our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with <30% polysomic cells. Polysomy had no prognostic significance on PFS or OS in patients with 1p/19q maintenance. Conclusions: The presence of polysomy in oligodendroglial tumors with codeletion of 1p/19q predicts early recurrence and short survival in patients with 1p/19q codeleted tumors.

KW - 1p/19q codeletion

KW - Glioma

KW - Oligodendroglioma

KW - Polysomy

UR - http://www.scopus.com/inward/record.url?scp=85073443859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073443859&partnerID=8YFLogxK

U2 - 10.1093/neuonc/noz098

DO - 10.1093/neuonc/noz098

M3 - Article

C2 - 31140557

AN - SCOPUS:85073443859

SN - 1522-8517

VL - 21

SP - 1164

EP - 1174

JO - Neuro-oncology

JF - Neuro-oncology

IS - 9

ER -

Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this