Polyvalent nucleic acid nanostructures

Joshua I. Cutler, Ke Zhang, Dan Zheng, Evelyn Auyeung, Andrew E. Prigodich, Chad A. Mirkin

Research output: Contribution to journalArticlepeer-review

118 Scopus citations

Abstract

Polyvalent oligonucleotide-nanoparticle conjugates possess several unique emergent properties, including enhanced cellular uptake, high antisense bioactivity, and nuclease resistance, which hypothetically originate from the dense packing and orientation of oligonucleotides on the surface of the nanoparticle. In this Communication, we describe a new class of polyvalent nucleic acid nanostructures (PNANs), which are comprised of only cross-linked and oriented nucleic acids. We demonstrate that these particles are capable of effecting high cellular uptake and gene regulation without the need of a cationic polymer co-carrier. The PNANs also exhibit cooperative binding behavior and nuclease resistance properties.

Original languageEnglish (US)
Pages (from-to)9254-9257
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number24
DOIs
StatePublished - Jun 22 2011

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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