Polyvalent oligonucleotide iron oxide nanoparticle "click" conjugates

Joshua I. Cutler, Dan Zheng, Xiaoyang Xu, David A. Giljohann, Chad A. Mirkin

Research output: Contribution to journalArticlepeer-review

120 Scopus citations


We have utilized the copper-catalyzed azide?alkyne reaction to form a dense monolayer of oligonucleotides on a superparamagnetic nanoparticle core. These particles exhibit the canonical properties of materials densely functionalized with DNA, which can be controlled by modulating the density of oligonucleotides on the surface of the particles. Furthermore, like their Au analogues, these particles can easily cross HeLa (cervical cancer) cell membranes without transfection agents due to their dense DNA shell. Importantly, this approach should be generalizable to other azide-functionalized particles.

Original languageEnglish (US)
Pages (from-to)1477-1480
Number of pages4
JournalNano letters
Issue number4
StatePublished - Apr 14 2010


  • Bioconjugation
  • Click
  • Cycloaddition
  • DNA
  • Nanomaterials

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanical Engineering
  • Bioengineering
  • General Chemistry
  • General Materials Science


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