Population balance model of in vivo neutrophil formation following bone marrow rescue therapy

L. K. Nielsen*, J. G. Bender, W. M. Miller, E. T. Papoutsakis

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In this paper, we develop a simple four parameter population balance model of in vivo neutrophil formation following bone marrow rescue therapy. The model is used to predict the number and type of neutrophil progenitors required to abrogate the period of severe neutropenia that normally follows a bone marrow transplant. The estimated total number of 5 billion neutrophil progenitors is consistent with the value extrapolated from a human trial. The model provides a basis for designing ex vivo expansion protocols.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalCytotechnology
Volume28
Issue number1-3
DOIs
StatePublished - 1998

Keywords

  • Bone marrow rescue therapy
  • Ex vivo expansion
  • In vivo model
  • Neutropenia

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Clinical Biochemistry
  • Cell Biology

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