Porous NiTi for bone implants: A review

A. Bansiddhi*, T. D. Sargeant, S. I. Stupp, D. C. Dunand

*Corresponding author for this work

Research output: Contribution to journalReview article

366 Scopus citations

Abstract

NiTi foams are unique among biocompatible porous metals because of their high recovery strain (due to the shape-memory or superelastic effects) and their low stiffness facilitating integration with bone structures. To optimize NiTi foams for bone implant applications, two key areas are under active study: synthesis of foams with optimal architectures, microstructure and mechanical properties; and tailoring of biological interactions through modifications of pore surfaces. This article reviews recent research on NiTi foams for bone replacement, focusing on three specific topics: (i) surface modifications designed to create bio-inert porous NiTi surfaces with low Ni release and corrosion, as well as bioactive surfaces to enhance and accelerate biological activity; (ii) in vitro and in vivo biocompatibility studies to confirm the long-term safety of porous NiTi implants; and (iii) biological evaluations for specific applications, such as in intervertebral fusion devices and bone tissue scaffolds. Possible future directions for bio-performance and processing studies are discussed that could lead to optimized porous NiTi implants.

Original languageEnglish (US)
Pages (from-to)773-782
Number of pages10
JournalActa Biomaterialia
Volume4
Issue number4
DOIs
StatePublished - Jul 1 2008

Keywords

  • Bioactive surfaces
  • Biocompatibility
  • Cellular metals
  • Chemical modification
  • Nitinol

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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