Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors

J. Burgdorf, R. A. Kroes, C. Weiss, M. M. Oh, J. F. Disterhoft, S. M. Brudzynski, J. Panksepp, J. R. Moskal*

*Corresponding author for this work

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

In rats, hedonic ultrasonic vocalizations (USVs) is a validated model of positive affect and is best elicited by rough-and-tumble play. Here we report that modulation of GluN2B-containing NMDA receptors (NMDAR) in the medial prefrontal cortex (MPFC) is involved in positive emotional learning. Rough and tumble play increased both GluN1 and GluN2B NMDAR subunit mRNA and protein levels in the frontal cortex. GLYX-13, a GluN2B-preferring, NMDAR glycine-site partial agonist (1 mg/kg, i.v.) significantly increased positive emotional learning whereas the GluN2B receptor-specific antagonist, ifenprodil (10 mg/kg, i.p.), inhibited positive emotional learning. Animals selectively bred for low rates of hedonic USVs were returned to wild-type levels of positive emotional learning following GLYX-13 treatment. MPFC microinjections of GLYX-13 (0.1-10 μg/side) significantly increased rates of positive emotional learning. Thus GluN2B-containing NMDARs may be involved in positive emotional learning in the MPFC by similar mechanisms as spatial/temporal learning in the hippocampus.

Original languageEnglish (US)
Pages (from-to)515-523
Number of pages9
JournalNeuroscience
Volume192
DOIs
StatePublished - Sep 29 2011

Fingerprint

Prefrontal Cortex
N-Methyl-D-Aspartate Receptors
Learning
Pleasure
Ultrasonics
Protein Subunits
Microinjections
Frontal Lobe
Glycine
Hippocampus
Messenger RNA

Keywords

  • GLYX-13
  • GluN2B
  • Learning
  • Medial prefrontal cortex
  • Positive emotion
  • Vocalizations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors",
abstract = "In rats, hedonic ultrasonic vocalizations (USVs) is a validated model of positive affect and is best elicited by rough-and-tumble play. Here we report that modulation of GluN2B-containing NMDA receptors (NMDAR) in the medial prefrontal cortex (MPFC) is involved in positive emotional learning. Rough and tumble play increased both GluN1 and GluN2B NMDAR subunit mRNA and protein levels in the frontal cortex. GLYX-13, a GluN2B-preferring, NMDAR glycine-site partial agonist (1 mg/kg, i.v.) significantly increased positive emotional learning whereas the GluN2B receptor-specific antagonist, ifenprodil (10 mg/kg, i.p.), inhibited positive emotional learning. Animals selectively bred for low rates of hedonic USVs were returned to wild-type levels of positive emotional learning following GLYX-13 treatment. MPFC microinjections of GLYX-13 (0.1-10 μg/side) significantly increased rates of positive emotional learning. Thus GluN2B-containing NMDARs may be involved in positive emotional learning in the MPFC by similar mechanisms as spatial/temporal learning in the hippocampus.",
keywords = "GLYX-13, GluN2B, Learning, Medial prefrontal cortex, Positive emotion, Vocalizations",
author = "J. Burgdorf and Kroes, {R. A.} and C. Weiss and Oh, {M. M.} and Disterhoft, {J. F.} and Brudzynski, {S. M.} and J. Panksepp and Moskal, {J. R.}",
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Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors. / Burgdorf, J.; Kroes, R. A.; Weiss, C.; Oh, M. M.; Disterhoft, J. F.; Brudzynski, S. M.; Panksepp, J.; Moskal, J. R.

In: Neuroscience, Vol. 192, 29.09.2011, p. 515-523.

Research output: Contribution to journalArticle

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T1 - Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors

AU - Burgdorf, J.

AU - Kroes, R. A.

AU - Weiss, C.

AU - Oh, M. M.

AU - Disterhoft, J. F.

AU - Brudzynski, S. M.

AU - Panksepp, J.

AU - Moskal, J. R.

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