Positive Remodeling of the Coronary Arteries Detected by Magnetic Resonance Imaging in an Asymptomatic Population. MESA (Multi-Ethnic Study of Atherosclerosis)

Cuilian Miao, Shaoguang Chen, Robson Macedo, Shenghan Lai, Kiang Liu, Debiao Li, Bruce A. Wasserman, Jens Vogel-Clausen, João A.C. Lima, David A. Bluemke*

*Corresponding author for this work

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

Objectives: The purpose of this study was to assess coronary arterial remodeling as a marker of subclinical atherosclerosis using coronary wall magnetic resonance imaging (MRI) in an asymptomatic population-based cohort. Background: In early atherosclerosis, compensatory enlargement of both the outer wall of the vessel as well as the lumen, termed compensatory enlargement or positive remodeling, occurs before luminal narrowing. Methods: One hundred seventy-nine participants in the MESA (Multi-Ethnic Study of Atherosclerosis) trial were evaluated using black-blood coronary wall MRI. Coronary cross-sectional area (vessel size), lumen area, and mean wall thickness of the proximal coronary arteries were measured. Results: Men had a greater vessel size, lumen area, and mean wall thickness than women (38.3 ± 11.3 mm2 vs. 32.6 ± 9.4 mm2, 6.7 ± 3.2 mm2 vs. 5.3 ± 2.4 mm2, and 2.0 ± 0.3 mm vs. 1.9 ± 0.3 mm, respectively, p < 0.05). No significant coronary artery narrowing was present by magnetic resonance angiography. Overall, coronary vessel size increased 25.9 mm2 per millimeter increase in coronary wall thickness, whereas lumen area increased only slightly at 3.1 mm2 for every millimeter increase in wall thickness (difference in slopes, p < 0.0001). Adjusting for age and sex, participants with an Agatston score >0 were more likely to have wall thickness >2.0 mm (odds ratio: 2.0, 95% confidence interval: 1.01 to 3.84). Conclusions: Coronary wall MRI detected positive arterial remodeling in asymptomatic men and women with subclinical atherosclerosis.

Original languageEnglish (US)
Pages (from-to)1708-1715
Number of pages8
JournalJournal of the American College of Cardiology
Volume53
Issue number18
DOIs
StatePublished - May 5 2009

Keywords

  • coronary artery disease
  • magnetic resonance imaging
  • plaque
  • subclinical atherosclerosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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