Possible involvement of human D minigenes in the first complementarity-determining region of κ light chains

P. P. Chen, E. A. Kabat, T. T. Wu, S. Fong, D. A. Carson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The nucleotide sequences of the complementary strands of two human diversity region (D) minigenes, D2 and D4, show stretches of homology with two human variable region κ chain (Vκ) genes, NG9 and HK101, respectively, in the first complementarity-determining region. In one Vκ sequence, the homology includes the 5' flanking region of D minigenes, which may comprise a recombinase recognition signal. It is thus conceivable that gene conversions involving D minigenes may contribute to Vκ diversity.

Original languageEnglish (US)
Pages (from-to)2125-2127
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume82
Issue number7
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • General

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