Possible use of similar framework region amino acid sequences between human and mouse immunoglobulins for humanizing mouse antibodies

Te Wu Tai Te Wu*, Elvin A. Kabat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

We have previously noted that a specific amino acid sequence could form the second framework region of human, mouse and rabbit immunoglobulin light chains, suggesting that this sequence has been preserved for 80 million years. Through divergent evolution, each species has acquired a different set of framework region sequences; however, these sets still share a few similar or identical amino acid sequences. In the present study, we have identified such sequences for all four framework regions between human and mouse immunoglobulin light and heavy chains. They may be useful in humanizing or reshaping mouse or rat antibodies for therapeutic applications in human patients.

Original languageEnglish (US)
Pages (from-to)1141-1146
Number of pages6
JournalMolecular Immunology
Volume29
Issue number9
DOIs
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Fingerprint

Dive into the research topics of 'Possible use of similar framework region amino acid sequences between human and mouse immunoglobulins for humanizing mouse antibodies'. Together they form a unique fingerprint.

Cite this