Post-Procedure Evaluation of Microwave Ablations of Hepatocellular Carcinomas Using Electrode Displacement Elastography

Wenjun Yang; Timothy J. Ziemlewicz; Tomy Varghese; Marci L. Alexander; Nicholas Rubert; Atul N. Ingle; Meghan G. Lubner; James L. Hinshaw; Shane A. Wells; Fred T. Lee; James A. Zagzebski

doi:10.1016/j.ultrasmedbio.2016.07.015

Post-Procedure Evaluation of Microwave Ablations of Hepatocellular Carcinomas Using Electrode Displacement Elastography

Wenjun Yang, Timothy J. Ziemlewicz, Tomy Varghese^*, Marci L. Alexander, Nicholas Rubert, Atul N. Ingle, Meghan G. Lubner, James L. Hinshaw, Shane A. Wells, Fred T. Lee, James A. Zagzebski

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Microwave ablation has been used clinically as an alternative to surgical resection. However, lack of real-time imaging to assess treated regions may compromise treatment outcomes. We previously introduced electrode displacement elastography (EDE) for strain imaging and verified its feasibility in vivo on porcine animal models. In this study, we evaluated EDE on 44 patients diagnosed with hepatocellular carcinoma, treated using microwave ablation. The ablated region was identified on EDE images for 40 of the 44 patients. Ablation areas averaged 13.38 ± 4.99 cm² on EDE, compared with 7.61 ± 3.21 cm² on B-mode imaging. Contrast and contrast-to-noise ratios obtained with EDE were 232% and 98%, respectively, significantly higher than values measured on B-mode images (p < 0.001). This study indicates that EDE is feasible in patients and provides improved visualization of the ablation zone compared with B-mode ultrasound.

Original language	English (US)
Pages (from-to)	2893-2902
Number of pages	10
Journal	Ultrasound in Medicine and Biology
Volume	42
Issue number	12
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2016.07.015
State	Published - Dec 1 2016

Keywords

Ablation
Elasticity imaging
Elastography
Hepatocellular carcinoma
Microwave ablation
Strain imaging

ASJC Scopus subject areas

Biophysics
Radiological and Ultrasound Technology
Acoustics and Ultrasonics

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10.1016/j.ultrasmedbio.2016.07.015

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Yang, W., Ziemlewicz, T. J., Varghese, T., Alexander, M. L., Rubert, N., Ingle, A. N., Lubner, M. G., Hinshaw, J. L., Wells, S. A., Lee, F. T., & Zagzebski, J. A. (2016). Post-Procedure Evaluation of Microwave Ablations of Hepatocellular Carcinomas Using Electrode Displacement Elastography. Ultrasound in Medicine and Biology, 42(12), 2893-2902. https://doi.org/10.1016/j.ultrasmedbio.2016.07.015

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title = "Post-Procedure Evaluation of Microwave Ablations of Hepatocellular Carcinomas Using Electrode Displacement Elastography",

abstract = "Microwave ablation has been used clinically as an alternative to surgical resection. However, lack of real-time imaging to assess treated regions may compromise treatment outcomes. We previously introduced electrode displacement elastography (EDE) for strain imaging and verified its feasibility in vivo on porcine animal models. In this study, we evaluated EDE on 44 patients diagnosed with hepatocellular carcinoma, treated using microwave ablation. The ablated region was identified on EDE images for 40 of the 44 patients. Ablation areas averaged 13.38 ± 4.99 cm2 on EDE, compared with 7.61 ± 3.21 cm2 on B-mode imaging. Contrast and contrast-to-noise ratios obtained with EDE were 232% and 98%, respectively, significantly higher than values measured on B-mode images (p < 0.001). This study indicates that EDE is feasible in patients and provides improved visualization of the ablation zone compared with B-mode ultrasound.",

keywords = "Ablation, Elasticity imaging, Elastography, Hepatocellular carcinoma, Microwave ablation, Strain imaging",

author = "Wenjun Yang and Ziemlewicz, {Timothy J.} and Tomy Varghese and Alexander, {Marci L.} and Nicholas Rubert and Ingle, {Atul N.} and Lubner, {Meghan G.} and Hinshaw, {James L.} and Wells, {Shane A.} and Lee, {Fred T.} and Zagzebski, {James A.}",

note = "Funding Information: This study was funded by National Institutes of Health Grant 2 R01 CA112192 . We are grateful to Siemens Medical Solutions USA, Inc., for providing the S2000 Axius Direct Ultrasound Research Interface (URI) and Software licenses. Publisher Copyright: {\textcopyright} 2016 World Federation for Ultrasound in Medicine & Biology",

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doi = "10.1016/j.ultrasmedbio.2016.07.015",

language = "English (US)",

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Yang, W, Ziemlewicz, TJ, Varghese, T, Alexander, ML, Rubert, N, Ingle, AN, Lubner, MG, Hinshaw, JL, Wells, SA, Lee, FT & Zagzebski, JA 2016, 'Post-Procedure Evaluation of Microwave Ablations of Hepatocellular Carcinomas Using Electrode Displacement Elastography', Ultrasound in Medicine and Biology, vol. 42, no. 12, pp. 2893-2902. https://doi.org/10.1016/j.ultrasmedbio.2016.07.015

TY - JOUR

T1 - Post-Procedure Evaluation of Microwave Ablations of Hepatocellular Carcinomas Using Electrode Displacement Elastography

AU - Yang, Wenjun

AU - Ziemlewicz, Timothy J.

AU - Varghese, Tomy

AU - Alexander, Marci L.

AU - Rubert, Nicholas

AU - Ingle, Atul N.

AU - Lubner, Meghan G.

AU - Hinshaw, James L.

AU - Wells, Shane A.

AU - Lee, Fred T.

AU - Zagzebski, James A.

N1 - Funding Information: This study was funded by National Institutes of Health Grant 2 R01 CA112192 . We are grateful to Siemens Medical Solutions USA, Inc., for providing the S2000 Axius Direct Ultrasound Research Interface (URI) and Software licenses. Publisher Copyright: © 2016 World Federation for Ultrasound in Medicine & Biology

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Microwave ablation has been used clinically as an alternative to surgical resection. However, lack of real-time imaging to assess treated regions may compromise treatment outcomes. We previously introduced electrode displacement elastography (EDE) for strain imaging and verified its feasibility in vivo on porcine animal models. In this study, we evaluated EDE on 44 patients diagnosed with hepatocellular carcinoma, treated using microwave ablation. The ablated region was identified on EDE images for 40 of the 44 patients. Ablation areas averaged 13.38 ± 4.99 cm2 on EDE, compared with 7.61 ± 3.21 cm2 on B-mode imaging. Contrast and contrast-to-noise ratios obtained with EDE were 232% and 98%, respectively, significantly higher than values measured on B-mode images (p < 0.001). This study indicates that EDE is feasible in patients and provides improved visualization of the ablation zone compared with B-mode ultrasound.

AB - Microwave ablation has been used clinically as an alternative to surgical resection. However, lack of real-time imaging to assess treated regions may compromise treatment outcomes. We previously introduced electrode displacement elastography (EDE) for strain imaging and verified its feasibility in vivo on porcine animal models. In this study, we evaluated EDE on 44 patients diagnosed with hepatocellular carcinoma, treated using microwave ablation. The ablated region was identified on EDE images for 40 of the 44 patients. Ablation areas averaged 13.38 ± 4.99 cm2 on EDE, compared with 7.61 ± 3.21 cm2 on B-mode imaging. Contrast and contrast-to-noise ratios obtained with EDE were 232% and 98%, respectively, significantly higher than values measured on B-mode images (p < 0.001). This study indicates that EDE is feasible in patients and provides improved visualization of the ablation zone compared with B-mode ultrasound.

KW - Ablation

KW - Elasticity imaging

KW - Elastography

KW - Hepatocellular carcinoma

KW - Microwave ablation

KW - Strain imaging

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AN - SCOPUS:84994508486

SN - 0301-5629

VL - 42

SP - 2893

EP - 2902

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

IS - 12

ER -

Post-Procedure Evaluation of Microwave Ablations of Hepatocellular Carcinomas Using Electrode Displacement Elastography

Abstract

Keywords

ASJC Scopus subject areas

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