Post-transplant diabetes mellitus in pediatric liver transplantation

Eba Hathout*, Estella Alonso, Ravinder Anand, Karen Martz, Essam Imseis, Joyce Johnston, James Lopez, Richard Chinnock, Sue McDiarmid

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

To determine the characteristics of pediatric liver transplant recipients who develop GI and/or PTDM, data on children undergoing their first liver transplant from the SPLIT database were analyzed (n = 1611). Recipient and donor characteristics that were evaluated included age at transplant, gender, race, primary disease, hospitalization status at transplant, BMI, recipient and donor CMV status, donor type, donor age, and primary immunosuppression. GI/PTDM was found in 214 individuals (13%) of whom 166 (78%) were diagnosed within 30 days of transplantation (early GI/PTDM). Multivariate analyses suggests that age >5 yr at transplant, hospitalization at transplant, a primary diagnosis other than BA, early steroid use, and tacrolimus use are associated with increased incidence of early GI. Routine monitoring for the development of GI and post-transplant diabetes is indicated in the short- and long-term care of children after liver transplantation.

Original languageEnglish (US)
Pages (from-to)599-605
Number of pages7
JournalPediatric transplantation
Volume13
Issue number5
DOIs
StatePublished - Aug 2009

Keywords

  • Immunosuppression
  • Islets
  • Liver transplantation
  • Pediatrics
  • Post-transplant diabetes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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