Posterior syphilitic uveitis: Clinical characteristics, co-infection with HIV, response to treatment

Sing Your Li*, Andrea D. Birnbaum, Howard H. Tessler, Debra A. Goldstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Purpose: To describe the characteristics and clinical course of patients with active posterior syphilitic uveitis evaluated between 1991 and 2009. Methods: Retrospective chart review. Results: Thirteen patients with active posterior syphilitic uveitis were identified at a single institution. All were men, and all with available data were men having sex with men (MSM). Ten of 12 (83%) with available data were HIV positive. Four (31%) had a history of syphilis. Clinical findings included infiltrative retinitis, necrotizing retinitis and optic neuritis. Two of 8 patients tested (25%) had a positive Venereal Disease Research Laboratory test in the cerebrospinal fluid. Treatments included intravenous penicillin, intramuscular penicillin and intramuscular ceftriaxone. All treated cases improved and, in some cases, inflammatory lesions completely resolved without scarring. Conclusions: In this series, syphilitic posterior uveitis presented only in men, and all with available data were MSM. The majority were concomitantly infected with HIV. Clinical presentations varied and all patients demonstrated either significant improvement or complete resolution of inflammation.

Original languageEnglish (US)
Pages (from-to)486-494
Number of pages9
JournalJapanese Journal of Ophthalmology
Volume55
Issue number5
DOIs
StatePublished - Sep 2011

Keywords

  • AIDS
  • HIV
  • Optic neuritis
  • Retinitis
  • Syphilis
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology

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