Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia

Girija Natarajan; Yvette R. Johnson; Beverly Brozanski; Kathryn N. Farrow; Isabella Zaniletti; Michael A. Padula; Jeanette M. Asselin; David J. Durand; Billie L. Short; Eugenia K. Pallotto; Francine D. Dykes; Kristina M. Reber; Jacquelyn R. Evans; Karna Murthy

doi:10.1055/s-0033-1345264

Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia

Girija Natarajan^*, Yvette R. Johnson, Beverly Brozanski, Kathryn N. Farrow, Isabella Zaniletti, Michael A. Padula, Jeanette M. Asselin, David J. Durand, Billie L. Short, Eugenia K. Pallotto, Francine D. Dykes, Kristina M. Reber, Jacquelyn R. Evans, Karna Murthy

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Objectives To characterize postnatal growth failure (PGF), defined as weight < 10th percentile for postmenstrual age (PMA) in preterm (≤ 27 weeks' gestation) infants with severe bronchopulmonary dysplasia (sBPD) at specified time points during hospitalization, and to compare these in subgroups of infants who died/underwent tracheostomy and others. Study Design Retrospective review of data from the multicenter Children's Hospital Neonatal Database (CHND). Results Our cohort (n = 375) had a mean ± standard deviation gestation of 25 ± 1.2 weeks and birth weight of 744 ± 196 g. At birth, 20% of infants were small for gestational age (SGA); age at referral to the CHND neonatal intensive care unit (NICU) was 46 ± 50 days. PGF rates at admission and at 36, 40, 44, and 48 weeks' PMA were 33, 53, 67, 66, and 79% of infants, respectively. Tube feedings were administered to > 70% and parenteral nutrition to a third of infants between 36 and 44 weeks' PMA. At discharge, 34% of infants required tube feedings and 50% had PGF. A significantly greater (38 versus 17%) proportion of infants who died/underwent tracheostomy (n = 69) were SGA, compared with those who did not (n = 306; p < 0.01). Conclusions Infants with sBPD commonly had progressive PGF during their NICU hospitalization. Fetal growth restriction may be a marker of adverse outcomes in this population.

Original language	English (US)
Pages (from-to)	223-230
Number of pages	8
Journal	American journal of perinatology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1055/s-0033-1345264
State	Published - Mar 2014

Keywords

bronchopulmonary dysplasia
growth
nutrition
tracheostomy

ASJC Scopus subject areas

Obstetrics and Gynecology
Pediatrics, Perinatology, and Child Health

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10.1055/s-0033-1345264

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Natarajan, G., Johnson, Y. R., Brozanski, B., Farrow, K. N., Zaniletti, I., Padula, M. A., Asselin, J. M., Durand, D. J., Short, B. L., Pallotto, E. K., Dykes, F. D., Reber, K. M., Evans, J. R., & Murthy, K. (2014). Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia. American journal of perinatology, 31(3), 223-230. https://doi.org/10.1055/s-0033-1345264

@article{7786dad1e7ce4c319dd6a3390c7a1bef,

title = "Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia",

abstract = "Objectives To characterize postnatal growth failure (PGF), defined as weight < 10th percentile for postmenstrual age (PMA) in preterm (≤ 27 weeks' gestation) infants with severe bronchopulmonary dysplasia (sBPD) at specified time points during hospitalization, and to compare these in subgroups of infants who died/underwent tracheostomy and others. Study Design Retrospective review of data from the multicenter Children's Hospital Neonatal Database (CHND). Results Our cohort (n = 375) had a mean ± standard deviation gestation of 25 ± 1.2 weeks and birth weight of 744 ± 196 g. At birth, 20% of infants were small for gestational age (SGA); age at referral to the CHND neonatal intensive care unit (NICU) was 46 ± 50 days. PGF rates at admission and at 36, 40, 44, and 48 weeks' PMA were 33, 53, 67, 66, and 79% of infants, respectively. Tube feedings were administered to > 70% and parenteral nutrition to a third of infants between 36 and 44 weeks' PMA. At discharge, 34% of infants required tube feedings and 50% had PGF. A significantly greater (38 versus 17%) proportion of infants who died/underwent tracheostomy (n = 69) were SGA, compared with those who did not (n = 306; p < 0.01). Conclusions Infants with sBPD commonly had progressive PGF during their NICU hospitalization. Fetal growth restriction may be a marker of adverse outcomes in this population.",

keywords = "bronchopulmonary dysplasia, growth, nutrition, tracheostomy",

author = "Girija Natarajan and Johnson, {Yvette R.} and Beverly Brozanski and Farrow, {Kathryn N.} and Isabella Zaniletti and Padula, {Michael A.} and Asselin, {Jeanette M.} and Durand, {David J.} and Short, {Billie L.} and Pallotto, {Eugenia K.} and Dykes, {Francine D.} and Reber, {Kristina M.} and Evans, {Jacquelyn R.} and Karna Murthy",

year = "2014",

month = mar,

doi = "10.1055/s-0033-1345264",

language = "English (US)",

volume = "31",

pages = "223--230",

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T1 - Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia

AU - Natarajan, Girija

AU - Johnson, Yvette R.

AU - Brozanski, Beverly

AU - Farrow, Kathryn N.

AU - Zaniletti, Isabella

AU - Padula, Michael A.

AU - Asselin, Jeanette M.

AU - Durand, David J.

AU - Short, Billie L.

AU - Pallotto, Eugenia K.

AU - Dykes, Francine D.

AU - Reber, Kristina M.

AU - Evans, Jacquelyn R.

AU - Murthy, Karna

PY - 2014/3

Y1 - 2014/3

N2 - Objectives To characterize postnatal growth failure (PGF), defined as weight < 10th percentile for postmenstrual age (PMA) in preterm (≤ 27 weeks' gestation) infants with severe bronchopulmonary dysplasia (sBPD) at specified time points during hospitalization, and to compare these in subgroups of infants who died/underwent tracheostomy and others. Study Design Retrospective review of data from the multicenter Children's Hospital Neonatal Database (CHND). Results Our cohort (n = 375) had a mean ± standard deviation gestation of 25 ± 1.2 weeks and birth weight of 744 ± 196 g. At birth, 20% of infants were small for gestational age (SGA); age at referral to the CHND neonatal intensive care unit (NICU) was 46 ± 50 days. PGF rates at admission and at 36, 40, 44, and 48 weeks' PMA were 33, 53, 67, 66, and 79% of infants, respectively. Tube feedings were administered to > 70% and parenteral nutrition to a third of infants between 36 and 44 weeks' PMA. At discharge, 34% of infants required tube feedings and 50% had PGF. A significantly greater (38 versus 17%) proportion of infants who died/underwent tracheostomy (n = 69) were SGA, compared with those who did not (n = 306; p < 0.01). Conclusions Infants with sBPD commonly had progressive PGF during their NICU hospitalization. Fetal growth restriction may be a marker of adverse outcomes in this population.

AB - Objectives To characterize postnatal growth failure (PGF), defined as weight < 10th percentile for postmenstrual age (PMA) in preterm (≤ 27 weeks' gestation) infants with severe bronchopulmonary dysplasia (sBPD) at specified time points during hospitalization, and to compare these in subgroups of infants who died/underwent tracheostomy and others. Study Design Retrospective review of data from the multicenter Children's Hospital Neonatal Database (CHND). Results Our cohort (n = 375) had a mean ± standard deviation gestation of 25 ± 1.2 weeks and birth weight of 744 ± 196 g. At birth, 20% of infants were small for gestational age (SGA); age at referral to the CHND neonatal intensive care unit (NICU) was 46 ± 50 days. PGF rates at admission and at 36, 40, 44, and 48 weeks' PMA were 33, 53, 67, 66, and 79% of infants, respectively. Tube feedings were administered to > 70% and parenteral nutrition to a third of infants between 36 and 44 weeks' PMA. At discharge, 34% of infants required tube feedings and 50% had PGF. A significantly greater (38 versus 17%) proportion of infants who died/underwent tracheostomy (n = 69) were SGA, compared with those who did not (n = 306; p < 0.01). Conclusions Infants with sBPD commonly had progressive PGF during their NICU hospitalization. Fetal growth restriction may be a marker of adverse outcomes in this population.

KW - bronchopulmonary dysplasia

KW - growth

KW - nutrition

KW - tracheostomy

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SN - 0735-1631

VL - 31

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EP - 230

JO - American journal of perinatology

JF - American journal of perinatology

IS - 3

ER -

Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia

Abstract

Keywords

ASJC Scopus subject areas

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