Postpartum angiopathy and other cerebral vasoconstriction syndromes

Aneesh B. Singhal*, Richard A. Bernstein

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


The phenomenon of reversible cerebral arterial segmental vasoconstriction has been associated with several conditions, including pregnancy and puerperium ("postpartum angiopathy"), thunderclap headache, and use of vasoconstrictive medications. Patients with cerebral vasoconstriction typically present with sudden, severe, and recurrent ("thunderclap") headaches and can develop strokes. Cerebral vasoconstriction syndromes are under-recognized, are poorly characterized, and are frequently misdiagnosed as primary cerebral vasculitis. This article presents an illustrative case report and reviews the historical aspects, clinical and imaging characteristics, etiology, differential diagnosis, management, and prognosis of cerebral vasoconstriction syndromes.

Original languageEnglish (US)
Pages (from-to)91-97
Number of pages7
JournalNeurocritical Care
Issue number1
StatePublished - Aug 2005


  • Benign angiopathy of the CNS
  • Call-fleming syndrome
  • Cerebral angiography
  • Cerebral ischemia
  • Cerebral vasospasm
  • Headache
  • Migraine
  • Postpartum angiopathy
  • Reversible posterior leukoencephalopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine


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