Postsurgical Cavity Evolution After Brain Metastasis Resection

How Soon Should Postoperative Radiosurgery Follow?

Rajal A. Patel*, Derrick Lock, Irene B. Helenowski, James P Chandler, Sean Sachdev, Matthew Christopher Tate, Timothy Joseph Kruser

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Postoperative stereotactic radiosurgery (SRS) to the cavity after resection of brain metastases improves local control. We hypothesized that significant cavity constriction would occur from the immediate postoperative period to the time of SRS and aimed to elucidate optimal treatment timing. Methods: We retrospectively reviewed 79 consecutive patients with 85 resection cavities treated with SRS after gross total resection of a brain metastasis. Preoperative lesion, immediate postoperative cavity, and cavity at the time of SRS were contoured for each patient. Factors influencing cavity size and interval cavity change were analyzed. Results: Median immediate postoperative cavity volume was 7.5 cm3, and median SRS cavity volume was 8.7 cm3. Median time from surgery to SRS was 20 days. Median volumetric cavity change was an increase of 28%. Of cavities, 34 (40%) increased in size >2 cm3, whereas only 8 cavities (9%) decreased in size >2 cm3; 43 cavities (51%) had ≤2 cm3 change. The largest postoperative cavities experienced the smallest percentage cavity change in the time interval to SRS (Spearman correlation −0.32, P = 0.003). Conclusions: Cavity size after brain metastasis resection increased a median of 28% from immediate postoperative scan to time of SRS. Greater than 90% of postoperative cavities either increased >2 cm3 or remained within 2 cm3 of their immediate postoperative cavity volume. Early postoperative SRS within 2–3 weeks may be appropriate to minimize cavity growth. Delaying postoperative SRS beyond 3 weeks in hopes of significant cavity contraction is not warranted.

Original languageEnglish (US)
Pages (from-to)e310-e314
JournalWorld Neurosurgery
Volume110
DOIs
StatePublished - Feb 1 2018

Fingerprint

Radiosurgery
Neoplasm Metastasis
Brain
Postoperative Period
Constriction

Keywords

  • Brain metastases
  • Cavity
  • Postoperative
  • Stereotactic Radiosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

@article{07821f13a64e418c87edc2cf86dc2aee,
title = "Postsurgical Cavity Evolution After Brain Metastasis Resection: How Soon Should Postoperative Radiosurgery Follow?",
abstract = "Background: Postoperative stereotactic radiosurgery (SRS) to the cavity after resection of brain metastases improves local control. We hypothesized that significant cavity constriction would occur from the immediate postoperative period to the time of SRS and aimed to elucidate optimal treatment timing. Methods: We retrospectively reviewed 79 consecutive patients with 85 resection cavities treated with SRS after gross total resection of a brain metastasis. Preoperative lesion, immediate postoperative cavity, and cavity at the time of SRS were contoured for each patient. Factors influencing cavity size and interval cavity change were analyzed. Results: Median immediate postoperative cavity volume was 7.5 cm3, and median SRS cavity volume was 8.7 cm3. Median time from surgery to SRS was 20 days. Median volumetric cavity change was an increase of 28{\%}. Of cavities, 34 (40{\%}) increased in size >2 cm3, whereas only 8 cavities (9{\%}) decreased in size >2 cm3; 43 cavities (51{\%}) had ≤2 cm3 change. The largest postoperative cavities experienced the smallest percentage cavity change in the time interval to SRS (Spearman correlation −0.32, P = 0.003). Conclusions: Cavity size after brain metastasis resection increased a median of 28{\%} from immediate postoperative scan to time of SRS. Greater than 90{\%} of postoperative cavities either increased >2 cm3 or remained within 2 cm3 of their immediate postoperative cavity volume. Early postoperative SRS within 2–3 weeks may be appropriate to minimize cavity growth. Delaying postoperative SRS beyond 3 weeks in hopes of significant cavity contraction is not warranted.",
keywords = "Brain metastases, Cavity, Postoperative, Stereotactic Radiosurgery",
author = "Patel, {Rajal A.} and Derrick Lock and Helenowski, {Irene B.} and Chandler, {James P} and Sean Sachdev and Tate, {Matthew Christopher} and Kruser, {Timothy Joseph}",
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day = "1",
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Postsurgical Cavity Evolution After Brain Metastasis Resection : How Soon Should Postoperative Radiosurgery Follow? / Patel, Rajal A.; Lock, Derrick; Helenowski, Irene B.; Chandler, James P; Sachdev, Sean; Tate, Matthew Christopher; Kruser, Timothy Joseph.

In: World Neurosurgery, Vol. 110, 01.02.2018, p. e310-e314.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Postsurgical Cavity Evolution After Brain Metastasis Resection

T2 - How Soon Should Postoperative Radiosurgery Follow?

AU - Patel, Rajal A.

AU - Lock, Derrick

AU - Helenowski, Irene B.

AU - Chandler, James P

AU - Sachdev, Sean

AU - Tate, Matthew Christopher

AU - Kruser, Timothy Joseph

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background: Postoperative stereotactic radiosurgery (SRS) to the cavity after resection of brain metastases improves local control. We hypothesized that significant cavity constriction would occur from the immediate postoperative period to the time of SRS and aimed to elucidate optimal treatment timing. Methods: We retrospectively reviewed 79 consecutive patients with 85 resection cavities treated with SRS after gross total resection of a brain metastasis. Preoperative lesion, immediate postoperative cavity, and cavity at the time of SRS were contoured for each patient. Factors influencing cavity size and interval cavity change were analyzed. Results: Median immediate postoperative cavity volume was 7.5 cm3, and median SRS cavity volume was 8.7 cm3. Median time from surgery to SRS was 20 days. Median volumetric cavity change was an increase of 28%. Of cavities, 34 (40%) increased in size >2 cm3, whereas only 8 cavities (9%) decreased in size >2 cm3; 43 cavities (51%) had ≤2 cm3 change. The largest postoperative cavities experienced the smallest percentage cavity change in the time interval to SRS (Spearman correlation −0.32, P = 0.003). Conclusions: Cavity size after brain metastasis resection increased a median of 28% from immediate postoperative scan to time of SRS. Greater than 90% of postoperative cavities either increased >2 cm3 or remained within 2 cm3 of their immediate postoperative cavity volume. Early postoperative SRS within 2–3 weeks may be appropriate to minimize cavity growth. Delaying postoperative SRS beyond 3 weeks in hopes of significant cavity contraction is not warranted.

AB - Background: Postoperative stereotactic radiosurgery (SRS) to the cavity after resection of brain metastases improves local control. We hypothesized that significant cavity constriction would occur from the immediate postoperative period to the time of SRS and aimed to elucidate optimal treatment timing. Methods: We retrospectively reviewed 79 consecutive patients with 85 resection cavities treated with SRS after gross total resection of a brain metastasis. Preoperative lesion, immediate postoperative cavity, and cavity at the time of SRS were contoured for each patient. Factors influencing cavity size and interval cavity change were analyzed. Results: Median immediate postoperative cavity volume was 7.5 cm3, and median SRS cavity volume was 8.7 cm3. Median time from surgery to SRS was 20 days. Median volumetric cavity change was an increase of 28%. Of cavities, 34 (40%) increased in size >2 cm3, whereas only 8 cavities (9%) decreased in size >2 cm3; 43 cavities (51%) had ≤2 cm3 change. The largest postoperative cavities experienced the smallest percentage cavity change in the time interval to SRS (Spearman correlation −0.32, P = 0.003). Conclusions: Cavity size after brain metastasis resection increased a median of 28% from immediate postoperative scan to time of SRS. Greater than 90% of postoperative cavities either increased >2 cm3 or remained within 2 cm3 of their immediate postoperative cavity volume. Early postoperative SRS within 2–3 weeks may be appropriate to minimize cavity growth. Delaying postoperative SRS beyond 3 weeks in hopes of significant cavity contraction is not warranted.

KW - Brain metastases

KW - Cavity

KW - Postoperative

KW - Stereotactic Radiosurgery

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U2 - 10.1016/j.wneu.2017.10.159

DO - 10.1016/j.wneu.2017.10.159

M3 - Article

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SP - e310-e314

JO - World Neurosurgery

JF - World Neurosurgery

SN - 1878-8750

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