Postsynaptic signaling and plasticity mechanisms

Morgan Sheng*, Myung Jong Kim

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

568 Scopus citations

Abstract

In excitatory synapses of the brain, specific receptors in the postsynaptic membrane lie ready to respond to the release of the neurotransmitter glutamate from the presynaptic terminal. Upon stimulation, these glutamate receptors activate multiple biochemical pathways that transduce signals into the postsynaptic neuron. Different kinds of synaptic activity elicit different patterns of postsynaptic signals that lead to short- or long-lasting strengthening or weakening of synaptic transmission. The complex molecular mechanisms that underlie postsynaptic signaling and plasticity are beginning to emerge.

Original languageEnglish (US)
Pages (from-to)776-780
Number of pages5
JournalScience
Volume298
Issue number5594
DOIs
StatePublished - Oct 25 2002

ASJC Scopus subject areas

  • Medicine(all)
  • General

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