TY - JOUR
T1 - Posttranslational mechanisms controlling centromere function and assembly
AU - Srivastava, Shashank
AU - Zasadzińska, Ewelina
AU - Foltz, Daniel R.
N1 - Funding Information:
Our sincere apologies to those we were unable to reference due to space limitations. D.R.F. was supported by NIH R01GM111907 and by a Zell Scholar award from the Robert H. Lurie Comprehensive Cancer Center.
Publisher Copyright:
© 2018
PY - 2018/6
Y1 - 2018/6
N2 - Accurate chromosome segregation is critical to ensure the faithful inheritance of the genome during cell division. Human chromosomes distinguish the location of the centromere from general chromatin by the selective assembly of CENP-A containing nucleosomes at the active centromere. The location of centromeres in most higher eukaryotes is determined epigenetically, independent of DNA sequence. CENP-A containing centromeric chromatin provides the foundation for assembly of the kinetochore that mediates chromosome attachment to the microtubule spindle and controls cell cycle progression in mitosis. Here we review recent work demonstrating the role of posttranslational modifications on centromere function and CENP-A inheritance via the direct modification of the CENP-A nucleosome and pre-nucleosomal complexes, the modification of the CENP-A deposition machinery and the modification of histones within existing centromeres.
AB - Accurate chromosome segregation is critical to ensure the faithful inheritance of the genome during cell division. Human chromosomes distinguish the location of the centromere from general chromatin by the selective assembly of CENP-A containing nucleosomes at the active centromere. The location of centromeres in most higher eukaryotes is determined epigenetically, independent of DNA sequence. CENP-A containing centromeric chromatin provides the foundation for assembly of the kinetochore that mediates chromosome attachment to the microtubule spindle and controls cell cycle progression in mitosis. Here we review recent work demonstrating the role of posttranslational modifications on centromere function and CENP-A inheritance via the direct modification of the CENP-A nucleosome and pre-nucleosomal complexes, the modification of the CENP-A deposition machinery and the modification of histones within existing centromeres.
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U2 - 10.1016/j.ceb.2018.03.003
DO - 10.1016/j.ceb.2018.03.003
M3 - Review article
C2 - 29621654
AN - SCOPUS:85051795889
VL - 52
SP - 126
EP - 135
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
ER -