Posttransplantation lymphoproliferative disease involving the pituitary gland

Zina Meriden, Grant C. Bullock, Adam Bagg, Hugo Bonatti, John B. Cousar, M. Beatriz Lopes, Mark K. Robbins, Helen P. Cathro

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Posttransplantation lymphoproliferative disorders (PTLD) are heterogeneous lesions with variable morphology, immunophenotype, and molecular characteristics. Multiple distinct primary lesions can occur in PTLD, rarely with both B-cell and T-cell characteristics. Lesions can involve both grafted organs and other sites; however, PTLD involving the pituitary gland has not been previously reported. We describe a patient who developed Epstein-Barr virus-negative PTLD 13 years posttransplantation involving the terminal ileum and pituitary, which was simultaneously involved by a pituitary adenoma. Immunohistochemistry of the pituitary lesion showed expression of CD79a, CD3, and CD7 with clonal rearrangements of both T-cell receptor gamma chain (TRG) and immunoglobulin heavy chain (IGH) genes. The terminal ileal lesion was immunophenotypically and molecularly distinct. This is the first report of pituitary PTLD and illustrates the potentially complex nature of PTLD.

Original languageEnglish (US)
Pages (from-to)1641-1645
Number of pages5
JournalHuman pathology
Issue number11
StatePublished - Nov 1 2010


  • B-cell lymphoma
  • EBV-negative
  • Pituitary
  • Posttransplantation lymphoproliferative disorder
  • T-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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