Postural sway and neurocognition in individuals meeting criteria for a clinical high-risk syndrome

K. Juston Osborne*, Vijay A. Mittal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Neurocognitive deficits are implicated in individuals that meet criteria for a clinical high-risk (CHR) syndrome. Evidence in patients with schizophrenia suggests that cerebellar dysfunction may underlie neurocognitive deficits. However, little research has examined if similar associations are present in those meeting CHR criteria. This study examined associations between the MATRICS cognitive battery, postural sway (an index of cerebellar functioning), and SIPS-RC psychosis risk scores in a CHR sample (N = 66). Poorer working memory and processing speed were associated with less postural control. Consistent with the cognitive dysmetria theory of schizophrenia, neurocognitive deficits are associated with cerebellar dysfunction in this critical population.

Original languageEnglish (US)
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
DOIs
StateAccepted/In press - 2021

Keywords

  • Cerebellum
  • Clinical high-risk
  • Neurocognition
  • Postural sway
  • Psychosis
  • Risk calculator

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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