Potent laminin-inspired antioxidant regenerative dressing accelerates wound healing in diabetes

Yunxiao Zhu, Zdravka Cankova, Marta Iwanaszko, Sheridan Lichtor, Milan Mrksich, Guillermo A. Ameer

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The successful treatment of chronic dermal wounds, such as diabetic foot ulcers (DFU), depends on the development of safe, effective, and affordable regenerative tools that the surgeon can rely on to promote wound closure. Although promising, strategies that involve cell-based therapies and the local release of exogenous growth factors are costly, require very long development times, and result in modest improvements in patient outcome. We describe the development of an antioxidant shape-conforming regenerative wound dressing that uses the laminin-derived dodecapeptide A5G81 as a potent tethered cell adhesion-, proliferation-, and haptokinesis-inducing ligand to locally promote wound closure. A5G81 immobilized within a thermoresponsive citrate-based hydrogel facilitates integrin-mediated spreading, migration, and proliferation of dermal and epidermal cells, resulting in faster tissue regeneration in diabetic wounds. This peptide-hydrogel system represents a paradigm shift in dermoconductive and dermoinductive strategies for treating DFU without the need for soluble biological or pharmacological factors.

Original languageEnglish (US)
Pages (from-to)6816-6821
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number26
DOIs
StatePublished - Jun 26 2018

Keywords

  • Citric acid
  • Diabetic foot ulcers
  • Laminin
  • Regenerative biomaterials
  • Wound healing

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Potent laminin-inspired antioxidant regenerative dressing accelerates wound healing in diabetes'. Together they form a unique fingerprint.

  • Cite this