Potential Application of Tissue Doppler Imaging to Assess Regional Left Ventricular Diastolic Function in Patients with Hypertrophic Cardiomyopathy: Comparison with 123I-β-Methyl Iodophenyl Pentadecanoic Acid Myocardial Scintigraphy

Hirotsugu Yamada, Takashi Oki, Takashi Yamamoto, Hideji Tanaka, Tomotsugu Tabata, Tetsuzo Wakatsuki, Masahiro Nomura, Susumu Ito, James D. Thomas*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Tissue Doppler imaging (TDI) has been utilized to evaluate left ventricular myocardial dysfunction in patients with hypertrophic cardiomyopathy (HCM); however, no clear explanation for the abnormality of TDI variables has been forthcoming. Hypothesis: Peak negative myocardial velocity gradient (MVG) derived from TDI may correlate with a disorder of fatty acid metabolism in patients with HCM. Methods: Tissue Doppler imaging and 123I-β-methyl iodophenyl pentadecanoic acid ( 123I-BMIPP) myocardial scintigraphy were performed in 15 patients with asymmetric septal hypertrophy (mean age 47 ± 18 years) and in 12 healthy controls (mean age 43 ± 10 years). Results: In early 123I-BMIPP images, accumulation defects were observed in the ventricular septumin 12 patients and in the posterior wall in 8 patients with HCM. Peak negative MVG in the ventricular septum (1.1 ± 0.5 vs. 2.8 ± 0.5, p<0.0001) and posterior wall (5.2 ± 1.4 vs. 6.7 ± 0,8, p< 0.01) was significantly lower in the HCM group than in the controls; also, these parameters were significantly lower in patients with than in those without a defect in the region in question. The peak negative MVG in the ventricular septum and posterior wall correlated inversely with the washout rate in all subjects. Conclusions: Peak negative MVG according to TDI is related to disorder of fatty acid metabolism in the regional left ventricular myocardium of patients with HCM.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalClinical Cardiology
Volume27
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Diastolic dysfunction
  • Hypertrophic cardiomyopathy
  • I-β-methyl iodophenyl pentadecanoic acid myocardial scintigraphy
  • Tissue Doppler imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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