Potential cardioprotective role of liver cell-secreted factors in myocardial ischemia

Shu Q. Liu, Yu H. Wu

Research output: Contribution to journalArticle

Abstract

Myocardial ischemia induces cardiomyocyte injury and death, resulting in impairment of cardiac function. As the endogenous protective function of adult cardiomyocytes is limited, nonmyocytic cells can be activated to protect myocardium from ischemic injury. In this article, we summarize nonmyocytic mechanisms involved in myocardial protection against ischemic injury. In particular, we review a novel concept of cardioprotection: upregulation of genes encoding liver cell-secreted factors in response to experimental myocardial ischemia and alleviation of acute myocardial infarction by administration of myocardial ischemia-conditioned liver cell extract. We present experimental evidence that supports this concept.
Original languageEnglish
Pages (from-to)65-77
JournalCurrent Topics in Biochemical Research
Volume11
StatePublished - 2009

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Myocardial Ischemia
Cardiac Myocytes
Liver
Wounds and Injuries
Liver Extracts
Cell Extracts
Myocardium
Up-Regulation
Myocardial Infarction
Genes

Cite this

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abstract = "Myocardial ischemia induces cardiomyocyte injury and death, resulting in impairment of cardiac function. As the endogenous protective function of adult cardiomyocytes is limited, nonmyocytic cells can be activated to protect myocardium from ischemic injury. In this article, we summarize nonmyocytic mechanisms involved in myocardial protection against ischemic injury. In particular, we review a novel concept of cardioprotection: upregulation of genes encoding liver cell-secreted factors in response to experimental myocardial ischemia and alleviation of acute myocardial infarction by administration of myocardial ischemia-conditioned liver cell extract. We present experimental evidence that supports this concept.",
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Potential cardioprotective role of liver cell-secreted factors in myocardial ischemia. / Liu, Shu Q.; Wu, Yu H.

In: Current Topics in Biochemical Research, Vol. 11, 2009, p. 65-77.

Research output: Contribution to journalArticle

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AB - Myocardial ischemia induces cardiomyocyte injury and death, resulting in impairment of cardiac function. As the endogenous protective function of adult cardiomyocytes is limited, nonmyocytic cells can be activated to protect myocardium from ischemic injury. In this article, we summarize nonmyocytic mechanisms involved in myocardial protection against ischemic injury. In particular, we review a novel concept of cardioprotection: upregulation of genes encoding liver cell-secreted factors in response to experimental myocardial ischemia and alleviation of acute myocardial infarction by administration of myocardial ischemia-conditioned liver cell extract. We present experimental evidence that supports this concept.

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