Abstract
Introduction Knee pain may preclude participation in higher intensity physical activity in people with knee osteoarthritis and benefits of light activity are unclear. The effect of replacing sedentary time with light intensity activity on incident functional limitation 2 years later was investigated. Methods Included were people with or at high risk of knee osteoarthritis without baseline functional limitation using data from the Osteoarthritis Initiative collected between August 2008 and July 2010. Data were analyzed between May 2016 and August 2016 for time in sedentary, light, and moderate to vigorous physical activity from accelerometer monitoring. Incident functional limitation was defined as (1) slow gait speed <1.0 meters/second during a 20-meter walk, (2) Western Ontario and McMasters University Osteoarthritis Index physical function ≥28, or (3) Short Form 12 Physical Component scale <40. Results Inclusion criteria were met by 1,873 people (mean age=65.0 [SD=9.0] years, mean BMI=28.4 [SD=4.7] kg/m2). Replacing 60 minutes/day of sedentary time with 60 minutes/day of light activity was associated with a 17% reduced risk for incident slow gait speed 2 years later (Hazard Ratio=0.83, 95% CI=0.70, 0.99) after adjustment. Approximately 5 minutes/day of moderate to vigorous physical activity would be necessary to receive the equivalent benefit of 60 minutes/day of light activity. Effects in secondary patient-reported outcomes did not reach statistical significance. Conclusions Replacing sedentary time with light activity may reduce the risk of performance-based functional limitation. As expected, moderate to vigorous physical activity rather than light provided stronger risk reduction. When moderate to vigorous physical activity is not an option, pursuing light activity may be a beneficial alternative to being sedentary.
Original language | English (US) |
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Pages (from-to) | 689-696 |
Number of pages | 8 |
Journal | American Journal of Preventive Medicine |
Volume | 53 |
Issue number | 5 |
DOIs | |
State | Published - Nov 2017 |
Funding
Funding for DKW was provided by NIH U54 GM104941 and K12 HD055931. Funding for DD, JL, and JS was provided by NIH 2R01-AR054155 and P60-AR064464. None of the funders of this manuscript had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. The Osteoarthritis Initiative (OAI) is a public–private partnership comprising five contracts (N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262) funded by NIH, a branch of the DHHS, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories, Novartis Pharmaceuticals Corporation, GlaxoSmithKline, and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. This manuscript was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, NIH, or the private funding partners. Dr. White and Dr. Dunlop had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. No author has any potential conflict of interest as related to this manuscript. All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years, and no other relationships or activities that could appear to have influenced the submitted work. DKW and DD were involved in conception and design of the study and in analysis and interpretation of the data. DD, JL, and JS were involved in collection of data. All authors were involved in the interpretation of data. DKW drafted the manuscript. All authors were involved in revision and final approval of the manuscript. All authors had full access to all of the data in the study. DKW and DD are the guarantors.
ASJC Scopus subject areas
- Epidemiology
- Public Health, Environmental and Occupational Health