Potential Implication of HLA-DQ Heterodimer High-Resolution Typing on Kidney Transplant Outcomes and Equity

Chelsea Maguire; Anat R. Tambur

doi:10.1007/s40472-023-00407-3

Potential Implication of HLA-DQ Heterodimer High-Resolution Typing on Kidney Transplant Outcomes and Equity

Chelsea Maguire, Anat R. Tambur^*

^*Corresponding author for this work

Surgery, Transplant Surgery Division

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of Review: To evaluate the potential implications of HLA-DQαβ heterodimer high-resolution typing on clinical decision-making in solid organ transplantation. Recent Finding: Lack of HLA-DQαβ heterodimer high-resolution typing information impacts cPRA calculations for patients on the waitlist and thus can affect their priority in organ allocation algorithms. It can further affect the number of potential compatible organ offers that they can receive. Summary: We believe that the compiled data highlight the need for a thorough evaluation by the OPTN/UNOS, to assure equity for patients in need of organ transplantation.

Original language	English (US)
Journal	Current Transplantation Reports
DOIs	https://doi.org/10.1007/s40472-023-00407-3
State	Accepted/In press - 2023

Keywords

Compatible donor
cPRA
Donor-specific antibody
HLA-antibody
HLA-DQ
Virtual crossmatch

ASJC Scopus subject areas

Surgery
Immunology
Hepatology
Nephrology
Transplantation

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10.1007/s40472-023-00407-3

Cite this

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title = "Potential Implication of HLA-DQ Heterodimer High-Resolution Typing on Kidney Transplant Outcomes and Equity",

abstract = "Purpose of Review: To evaluate the potential implications of HLA-DQαβ heterodimer high-resolution typing on clinical decision-making in solid organ transplantation. Recent Finding: Lack of HLA-DQαβ heterodimer high-resolution typing information impacts cPRA calculations for patients on the waitlist and thus can affect their priority in organ allocation algorithms. It can further affect the number of potential compatible organ offers that they can receive. Summary: We believe that the compiled data highlight the need for a thorough evaluation by the OPTN/UNOS, to assure equity for patients in need of organ transplantation.",

keywords = "Compatible donor, cPRA, Donor-specific antibody, HLA-antibody, HLA-DQ, Virtual crossmatch",

author = "Chelsea Maguire and Tambur, {Anat R.}",

note = "Funding Information: Some of this work was funded by a generous contribution from the Paul I. Terasaki Memorial Research Fund. Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.",

year = "2023",

doi = "10.1007/s40472-023-00407-3",

language = "English (US)",

journal = "Current Transplantation Reports",

issn = "2196-3029",

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TY - JOUR

T1 - Potential Implication of HLA-DQ Heterodimer High-Resolution Typing on Kidney Transplant Outcomes and Equity

AU - Maguire, Chelsea

AU - Tambur, Anat R.

N1 - Funding Information: Some of this work was funded by a generous contribution from the Paul I. Terasaki Memorial Research Fund. Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

PY - 2023

Y1 - 2023

N2 - Purpose of Review: To evaluate the potential implications of HLA-DQαβ heterodimer high-resolution typing on clinical decision-making in solid organ transplantation. Recent Finding: Lack of HLA-DQαβ heterodimer high-resolution typing information impacts cPRA calculations for patients on the waitlist and thus can affect their priority in organ allocation algorithms. It can further affect the number of potential compatible organ offers that they can receive. Summary: We believe that the compiled data highlight the need for a thorough evaluation by the OPTN/UNOS, to assure equity for patients in need of organ transplantation.

AB - Purpose of Review: To evaluate the potential implications of HLA-DQαβ heterodimer high-resolution typing on clinical decision-making in solid organ transplantation. Recent Finding: Lack of HLA-DQαβ heterodimer high-resolution typing information impacts cPRA calculations for patients on the waitlist and thus can affect their priority in organ allocation algorithms. It can further affect the number of potential compatible organ offers that they can receive. Summary: We believe that the compiled data highlight the need for a thorough evaluation by the OPTN/UNOS, to assure equity for patients in need of organ transplantation.

KW - Compatible donor

KW - cPRA

KW - Donor-specific antibody

KW - HLA-antibody

KW - HLA-DQ

KW - Virtual crossmatch

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DO - 10.1007/s40472-023-00407-3

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JO - Current Transplantation Reports

JF - Current Transplantation Reports

ER -

Potential Implication of HLA-DQ Heterodimer High-Resolution Typing on Kidney Transplant Outcomes and Equity

Abstract

Keywords

ASJC Scopus subject areas

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