Potential mechanism of vasomotor dysregulation after lung transplantation for primary pulmonary hypertension

S. J. Mentzer*, J. J. Reilly, M. DeCamp, D. J. Sugarbaker, D. V. Faller

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: Vasomotor regulation in the lung is controlled by a dynamic balance between humoral factors and autonomic innervation. Lung transplantation is a unique clinical situation in which vasoregulation is dependent on humoral factors alone. Methods: We illustrate the problem of vasomotor dysregulation with a lung transplant recipient in whom life- threatening hypoxemia was dramatically reversed with the administration of organic nitrates. The potential mechanism for this dysregulation was explored by exposing human endothelial cells to hypoxic conditions in vitro and analyzing the cells for the expression of pulmonary vasoconstrictor gone transcripts. Results: The hypoxic microenvironment induced a tenfold increase in the transcription of the pulmonary vasoconstrictor genes endothelin-1 and platelet-derived growth factor within 24 hours. The addition of organic nitrates had a dramatic effect on decreasing the levels of vasoconstrictor transcripts within 30 minutes of exposure. Conclusion: These findings suggest that a potential mechanism for the clinical effect of organic nitrates is the inhibition of vasoconstrictor synthesis by hypoxic endothelium.

Original languageEnglish (US)
Pages (from-to)387-393
Number of pages7
JournalJournal of Heart and Lung Transplantation
Volume14
Issue number2
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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    Mentzer, S. J., Reilly, J. J., DeCamp, M., Sugarbaker, D. J., & Faller, D. V. (1995). Potential mechanism of vasomotor dysregulation after lung transplantation for primary pulmonary hypertension. Journal of Heart and Lung Transplantation, 14(2), 387-393.