Potential new therapies for pediatric diffuse intrinsic pontine glioma

Wenyong Long, Yang Yi, Shen Chen, Qi Cao, Wei Zhao*, Qing Liu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems.

Original languageEnglish (US)
Article number495
JournalFrontiers in Pharmacology
Issue numberJUL
StatePublished - Jul 25 2017


  • DIPG
  • Epigenetic therapy
  • H3K27M
  • Immunotherapy
  • Nanoparticles
  • Stem cells

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology


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