Potential Prognostic Value of Native T1 in Pulmonary Hypertension Patients

John W. Cerne, Christina Shehata*, Ann Ragin, Ashitha Pathrose, Manik Veer, Kamal Subedi, Bradley D. Allen, Ryan J. Avery, Michael Markl, James C. Carr

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Native T1, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) characterize myocardial tissue and relate to patient prognosis in a variety of diseases, including pulmonary hypertension. The purpose of this study was to evaluate if left ventricle (LV) fibrosis measurements have prognostic value for cardiac outcomes in pulmonary hypertension subgroups. 54 patients with suspected pulmonary hypertension underwent right-heart catheterization and were classified into pulmonary hypertension subgroups: pre-capillary component (PreCompPH) and isolated post-capillary (IpcPH). Cardiac magnetic resonance imaging (MRI) scans were performed with the acquisition of balanced cine steady-state free precession, native T1, and LGE pulse sequences to measure cardiac volumes and myocardial fibrosis. Associations between cardiac events and cardiac MRI measurements were analyzed within PreCompPH and IpcPH patients. IpcPH: LV native T1 was higher in patients who experienced a cardiac event within two years vs. those who did not. In patients with LV native T1 > 1050 ms, the rate of cardiac events was higher. ECV and quantitative LGE did not differ between groups. PreCompPH: native T1, ECV, and quantitative/qualitative LGE did not differ between patients who experienced a cardiac event within two years vs. those who did not. LV native T1 may have potential value for forecasting cardiac events in IpcPH, but not in PreCompPH, patients.

Original languageEnglish (US)
Article number775
JournalLife
Volume13
Issue number3
DOIs
StatePublished - Mar 2023

Funding

This research was supported by Bayer HealthCare Pharmaceuticals Inc. (reference award number: Carr-IIR-US-2017-3822). All funding was directed towards the research protocol execution. The funding body played no role in the study design, data collection, data analysis, or manuscript writing. JCC is the principal investigator for this Bayer funded study. JCC declares that he has previously participated in advisory boards for Bayer, Guerbet and Bracco. JCC participates in speaking roles sponsored by Bayer. JCC has received institutional research support sponsored by Bayer, Guerbet, and Siemens. MM has received research support from Siemens. MM has received research grants from Circle Cardiovascular imaging and Cryolife incorporated. BDA and RJA have performed consulting for Circle Cardiovascular Imaging. The other authors declare that they have no competing interests.

Keywords

  • extracellular volume fraction
  • late gadolinium enhancement
  • native T1
  • patient outcomes
  • pulmonary hypertension

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • General Biochemistry, Genetics and Molecular Biology
  • Space and Planetary Science
  • Palaeontology

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