Potential Prognostic Value of Native T1 in Pulmonary Hypertension Patients

John W. Cerne; Christina Shehata; Ann Ragin; Ashitha Pathrose; Manik Veer; Kamal Subedi; Bradley D. Allen; Ryan J. Avery; Michael Markl; James C. Carr

doi:10.3390/life13030775

Potential Prognostic Value of Native T1 in Pulmonary Hypertension Patients

John W. Cerne, Christina Shehata^*, Ann Ragin, Ashitha Pathrose, Manik Veer, Kamal Subedi, Bradley D. Allen, Ryan J. Avery, Michael Markl, James C. Carr

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

Abstract

Native T1, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) characterize myocardial tissue and relate to patient prognosis in a variety of diseases, including pulmonary hypertension. The purpose of this study was to evaluate if left ventricle (LV) fibrosis measurements have prognostic value for cardiac outcomes in pulmonary hypertension subgroups. 54 patients with suspected pulmonary hypertension underwent right-heart catheterization and were classified into pulmonary hypertension subgroups: pre-capillary component (PreCompPH) and isolated post-capillary (IpcPH). Cardiac magnetic resonance imaging (MRI) scans were performed with the acquisition of balanced cine steady-state free precession, native T1, and LGE pulse sequences to measure cardiac volumes and myocardial fibrosis. Associations between cardiac events and cardiac MRI measurements were analyzed within PreCompPH and IpcPH patients. IpcPH: LV native T1 was higher in patients who experienced a cardiac event within two years vs. those who did not. In patients with LV native T1 > 1050 ms, the rate of cardiac events was higher. ECV and quantitative LGE did not differ between groups. PreCompPH: native T1, ECV, and quantitative/qualitative LGE did not differ between patients who experienced a cardiac event within two years vs. those who did not. LV native T1 may have potential value for forecasting cardiac events in IpcPH, but not in PreCompPH, patients.

Original language	English (US)
Article number	775
Journal	Life
Volume	13
Issue number	3
DOIs	https://doi.org/10.3390/life13030775
State	Published - Mar 2023

Funding

This research was supported by Bayer HealthCare Pharmaceuticals Inc. (reference award number: Carr-IIR-US-2017-3822). All funding was directed towards the research protocol execution. The funding body played no role in the study design, data collection, data analysis, or manuscript writing. JCC is the principal investigator for this Bayer funded study. JCC declares that he has previously participated in advisory boards for Bayer, Guerbet and Bracco. JCC participates in speaking roles sponsored by Bayer. JCC has received institutional research support sponsored by Bayer, Guerbet, and Siemens. MM has received research support from Siemens. MM has received research grants from Circle Cardiovascular imaging and Cryolife incorporated. BDA and RJA have performed consulting for Circle Cardiovascular Imaging. The other authors declare that they have no competing interests.

Keywords

extracellular volume fraction
late gadolinium enhancement
native T1
patient outcomes
pulmonary hypertension

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
General Biochemistry, Genetics and Molecular Biology
Space and Planetary Science
Palaeontology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/life13030775

Cite this

@article{95fc6f33f8a64668b8bdaebfee573858,

title = "Potential Prognostic Value of Native T1 in Pulmonary Hypertension Patients",

abstract = "Native T1, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) characterize myocardial tissue and relate to patient prognosis in a variety of diseases, including pulmonary hypertension. The purpose of this study was to evaluate if left ventricle (LV) fibrosis measurements have prognostic value for cardiac outcomes in pulmonary hypertension subgroups. 54 patients with suspected pulmonary hypertension underwent right-heart catheterization and were classified into pulmonary hypertension subgroups: pre-capillary component (PreCompPH) and isolated post-capillary (IpcPH). Cardiac magnetic resonance imaging (MRI) scans were performed with the acquisition of balanced cine steady-state free precession, native T1, and LGE pulse sequences to measure cardiac volumes and myocardial fibrosis. Associations between cardiac events and cardiac MRI measurements were analyzed within PreCompPH and IpcPH patients. IpcPH: LV native T1 was higher in patients who experienced a cardiac event within two years vs. those who did not. In patients with LV native T1 > 1050 ms, the rate of cardiac events was higher. ECV and quantitative LGE did not differ between groups. PreCompPH: native T1, ECV, and quantitative/qualitative LGE did not differ between patients who experienced a cardiac event within two years vs. those who did not. LV native T1 may have potential value for forecasting cardiac events in IpcPH, but not in PreCompPH, patients.",

keywords = "extracellular volume fraction, late gadolinium enhancement, native T1, patient outcomes, pulmonary hypertension",

author = "Cerne, {John W.} and Christina Shehata and Ann Ragin and Ashitha Pathrose and Manik Veer and Kamal Subedi and Allen, {Bradley D.} and Avery, {Ryan J.} and Michael Markl and Carr, {James C.}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = mar,

doi = "10.3390/life13030775",

language = "English (US)",

volume = "13",

journal = "Life",

issn = "0024-3019",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

TY - JOUR

T1 - Potential Prognostic Value of Native T1 in Pulmonary Hypertension Patients

AU - Cerne, John W.

AU - Shehata, Christina

AU - Ragin, Ann

AU - Pathrose, Ashitha

AU - Veer, Manik

AU - Subedi, Kamal

AU - Allen, Bradley D.

AU - Avery, Ryan J.

AU - Markl, Michael

AU - Carr, James C.

PY - 2023/3

Y1 - 2023/3

N2 - Native T1, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) characterize myocardial tissue and relate to patient prognosis in a variety of diseases, including pulmonary hypertension. The purpose of this study was to evaluate if left ventricle (LV) fibrosis measurements have prognostic value for cardiac outcomes in pulmonary hypertension subgroups. 54 patients with suspected pulmonary hypertension underwent right-heart catheterization and were classified into pulmonary hypertension subgroups: pre-capillary component (PreCompPH) and isolated post-capillary (IpcPH). Cardiac magnetic resonance imaging (MRI) scans were performed with the acquisition of balanced cine steady-state free precession, native T1, and LGE pulse sequences to measure cardiac volumes and myocardial fibrosis. Associations between cardiac events and cardiac MRI measurements were analyzed within PreCompPH and IpcPH patients. IpcPH: LV native T1 was higher in patients who experienced a cardiac event within two years vs. those who did not. In patients with LV native T1 > 1050 ms, the rate of cardiac events was higher. ECV and quantitative LGE did not differ between groups. PreCompPH: native T1, ECV, and quantitative/qualitative LGE did not differ between patients who experienced a cardiac event within two years vs. those who did not. LV native T1 may have potential value for forecasting cardiac events in IpcPH, but not in PreCompPH, patients.

AB - Native T1, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) characterize myocardial tissue and relate to patient prognosis in a variety of diseases, including pulmonary hypertension. The purpose of this study was to evaluate if left ventricle (LV) fibrosis measurements have prognostic value for cardiac outcomes in pulmonary hypertension subgroups. 54 patients with suspected pulmonary hypertension underwent right-heart catheterization and were classified into pulmonary hypertension subgroups: pre-capillary component (PreCompPH) and isolated post-capillary (IpcPH). Cardiac magnetic resonance imaging (MRI) scans were performed with the acquisition of balanced cine steady-state free precession, native T1, and LGE pulse sequences to measure cardiac volumes and myocardial fibrosis. Associations between cardiac events and cardiac MRI measurements were analyzed within PreCompPH and IpcPH patients. IpcPH: LV native T1 was higher in patients who experienced a cardiac event within two years vs. those who did not. In patients with LV native T1 > 1050 ms, the rate of cardiac events was higher. ECV and quantitative LGE did not differ between groups. PreCompPH: native T1, ECV, and quantitative/qualitative LGE did not differ between patients who experienced a cardiac event within two years vs. those who did not. LV native T1 may have potential value for forecasting cardiac events in IpcPH, but not in PreCompPH, patients.

KW - extracellular volume fraction

KW - late gadolinium enhancement

KW - native T1

KW - patient outcomes

KW - pulmonary hypertension

UR - http://www.scopus.com/inward/record.url?scp=85151664337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85151664337&partnerID=8YFLogxK

U2 - 10.3390/life13030775

DO - 10.3390/life13030775

M3 - Article

C2 - 36983931

AN - SCOPUS:85151664337

SN - 0024-3019

VL - 13

JO - Life

JF - Life

IS - 3

M1 - 775

ER -

Potential Prognostic Value of Native T1 in Pulmonary Hypertension Patients

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this