Potential targeting of siglecs, mast cell inhibitory receptors, in interstitial cystitis

Chang Shin Park; Bruce S. Bochner

doi:10.5213/inj.2011.15.2.61

Potential targeting of siglecs, mast cell inhibitory receptors, in interstitial cystitis

Chang Shin Park^*, Bruce S. Bochner

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Mast cell increases and activation are detected in the chronic inflammatory bladder disease interstitial cystitis (IC), and their proinflammatory mediators are felt to contribute to regional pelvic pain and inflammatory pathophysiology. The immunoreceptor tyrosine-based inhibition motif-containing sialic acid-binding immunoglobulin-like lectins (Siglecs) expressed in mast cells could be evaluated as in vivo signaling regulators capable of inhibiting IC-related mast cell activation.

Original language	English (US)
Pages (from-to)	61-63
Number of pages	3
Journal	International Neurourology Journal
Volume	15
Issue number	2
DOIs	https://doi.org/10.5213/inj.2011.15.2.61
State	Published - Jun 2011

Keywords

Interstitial cystitis
Mast cells
Sialic acid binding Ig-like lectin (Siglec)
Urinary bladder

ASJC Scopus subject areas

Clinical Neurology
Neurology
Urology

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10.5213/inj.2011.15.2.61

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abstract = "Mast cell increases and activation are detected in the chronic inflammatory bladder disease interstitial cystitis (IC), and their proinflammatory mediators are felt to contribute to regional pelvic pain and inflammatory pathophysiology. The immunoreceptor tyrosine-based inhibition motif-containing sialic acid-binding immunoglobulin-like lectins (Siglecs) expressed in mast cells could be evaluated as in vivo signaling regulators capable of inhibiting IC-related mast cell activation.",

keywords = "Interstitial cystitis, Mast cells, Sialic acid binding Ig-like lectin (Siglec), Urinary bladder",

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AU - Bochner, Bruce S.

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AB - Mast cell increases and activation are detected in the chronic inflammatory bladder disease interstitial cystitis (IC), and their proinflammatory mediators are felt to contribute to regional pelvic pain and inflammatory pathophysiology. The immunoreceptor tyrosine-based inhibition motif-containing sialic acid-binding immunoglobulin-like lectins (Siglecs) expressed in mast cells could be evaluated as in vivo signaling regulators capable of inhibiting IC-related mast cell activation.

KW - Interstitial cystitis

KW - Mast cells

KW - Sialic acid binding Ig-like lectin (Siglec)

KW - Urinary bladder

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Potential targeting of siglecs, mast cell inhibitory receptors, in interstitial cystitis

Abstract

Keywords

ASJC Scopus subject areas

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