PPAR activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation

Yan J. Jiang, Grant Barish, Biao Lu, Ronald M. Evans, Debra Crumrine, Matthias Schmuth, Peter M. Elias, Kenneth R. Feingold

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The goal of epidermal ontogenesis is to form a stratum corneum (SC), which is required for post-natal permeability barrier function. The regulation of epidermal ontogenesis is poorly understood, but nuclear hormone receptors have been shown to have an important function. As peroxisome proliferator-activated receptor-(PPAR) is very abundant in fetal epidermis and PPAR activation stimulates differentiation and permeability barrier formation in adults, we hypothesized that PPAR might regulate epidermal ontogenesis. Treatment of fetal rat explants with the PPAR ligand, GW 610742X, accelerates permeability barrier development, evidenced by a decrease in transepidermal water loss and an enhanced outside-in barrier function, attributable to the presence of more mature lamellar membranes in the SC and enhanced expression of loricrin and involucrin. Similarly, the intra-amniotic administration of GW 610742X also accelerates the formation of the SC and permeability barrier development. Finally, in PPAR-deficient mice the formation of the SC and the expression of differentiation-related proteins were delayed on days 16.5 and 17.5 of gestation. However, at later stages (day 18.5 and after birth), there were no differences between wild-type-and PPAR-deficient mice, indicating only a transient delay in epidermal ontogenesis. These studies show that PPAR has a role in SC formation and permeability barrier development.

Original languageEnglish (US)
Pages (from-to)511-519
Number of pages9
JournalJournal of Investigative Dermatology
Volume130
Issue number2
DOIs
StatePublished - Feb 2010

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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