PPARs and the complex journey to obesity

Ronald M. Evans*, Grant D. Barish, Yong Xu Wang

*Corresponding author for this work

Research output: Contribution to journalReview article

1129 Scopus citations

Abstract

Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, the elucidation of key regulators of energy balance and insulin signaling have revolutionized our understanding of fat and sugar metabolism and their intimate link. The three 'lipid-sensing' peroxisome proliferator-activated receptors (PPAR-α, PPAR-γ and PPAR-δ) exemplify this connection, regulating diverse aspects of lipid and glucose homeostasis, and serving as bona fide therapeutic targets. With molecular underpinnings now in place, new pharmacologic approaches to metabolic disease and new questions are emerging.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalNature Medicine
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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