TY - JOUR
T1 - Practical molecular diagnostics in neuropathology
T2 - Making a tough job a little easier
AU - Horbinski, Craig
PY - 2010/5
Y1 - 2010/5
N2 - Neuropathology is a challenging field, in large part because of the consequential decisions that must be made with small biopsy material. This is especially true concerning the most common primary brain tumor, the infiltrative glioma. Fortunately, abundant research has identified specific molecular alterations that are characteristic of gliomas, according to diagnostic class and tumor grade. Such alterations include 1p19q codeletion, EGFR amplification, p16 deletion, and IDH1/2 mutations. Using specific cases as examples, this review illustrates how molecular testing is of great help in avoiding misdiagnoses and enhancing the quality of information provided to clinicians.
AB - Neuropathology is a challenging field, in large part because of the consequential decisions that must be made with small biopsy material. This is especially true concerning the most common primary brain tumor, the infiltrative glioma. Fortunately, abundant research has identified specific molecular alterations that are characteristic of gliomas, according to diagnostic class and tumor grade. Such alterations include 1p19q codeletion, EGFR amplification, p16 deletion, and IDH1/2 mutations. Using specific cases as examples, this review illustrates how molecular testing is of great help in avoiding misdiagnoses and enhancing the quality of information provided to clinicians.
KW - 1p19q
KW - EGFR
KW - IDH1
KW - P16
UR - http://www.scopus.com/inward/record.url?scp=77955254003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955254003&partnerID=8YFLogxK
U2 - 10.1053/j.semdp.2010.04.001
DO - 10.1053/j.semdp.2010.04.001
M3 - Article
C2 - 20860314
AN - SCOPUS:77955254003
SN - 0740-2570
VL - 27
SP - 105
EP - 113
JO - Seminars in Diagnostic Pathology
JF - Seminars in Diagnostic Pathology
IS - 2
ER -