Practical molecular diagnostics in neuropathology: Making a tough job a little easier

Craig Horbinski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Neuropathology is a challenging field, in large part because of the consequential decisions that must be made with small biopsy material. This is especially true concerning the most common primary brain tumor, the infiltrative glioma. Fortunately, abundant research has identified specific molecular alterations that are characteristic of gliomas, according to diagnostic class and tumor grade. Such alterations include 1p19q codeletion, EGFR amplification, p16 deletion, and IDH1/2 mutations. Using specific cases as examples, this review illustrates how molecular testing is of great help in avoiding misdiagnoses and enhancing the quality of information provided to clinicians.

Original languageEnglish (US)
Pages (from-to)105-113
Number of pages9
JournalSeminars in Diagnostic Pathology
Volume27
Issue number2
DOIs
StatePublished - May 2010

Keywords

  • 1p19q
  • EGFR
  • IDH1
  • P16

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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