Pre-mRNA splicing and retinitis pigmentosa

Daniel Mordes, Xiaoyan Luo, Amar Kar, David Kuo, Lili Xu, Kazuo Fushimi, Guowu Yu, Paul Sternberg, Jane Y. Wu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


Retinitis pigmentosa (RP) is a group of genetically and clinically heterogeneous retinal diseases and a common cause of blindness. Among the 12 autosomal dominant RP (adRP) genes identified, four encode ubiquitously expressed proteins involved in pre-mRNA splicing, demonstrating the important role that pre-mRNA splicing plays in the pathogenesis of retinal degeneration. This review focuses on recent progress in identifying adRP mutations in genes encoding pre-mRNA splicing factors and the potential underlying molecular mechanisms.

Original languageEnglish (US)
Pages (from-to)1259-1271
Number of pages13
JournalMolecular vision
StatePublished - Oct 26 2006

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Pre-mRNA splicing and retinitis pigmentosa'. Together they form a unique fingerprint.

Cite this