Pre-pregnancy obesity and maternal nutritional biomarker status during pregnancy: A factor analysis

Laura E. Tomedi, Chung Chou H Chang, P. K. Newby, Rhobert W. Evans, James F. Luther, Katherine L. Wisner, Lisa M. Bodnar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Objective Pre-pregnancy obesity has been associated with adverse birth outcomes. Poor essential fatty acid (EFA) and micronutrient status during pregnancy may contribute to these associations. We assessed the associations between pre-pregnancy BMI and nutritional patterns of maternal micronutrient and EFA status during mid-pregnancy. Design A cross-sectional analysis from a prospective cohort study. Women provided non-fasting blood samples at ≤20 weeks' gestation that were assayed for red cell EFA; plasma folate, homocysteine and ascorbic acid; and serum retinol, 25-hydroxyvitamin D, α-tocopherol, soluble transferrin receptors and carotenoids. These nutritional biomarkers were employed in a factor analysis and three patterns were derived: EFA, Micronutrients and Carotenoids. Setting The Antidepressant Use During Pregnancy Study, Pittsburgh, PA, USA. Subjects Pregnant women (n 129). Results After adjustment for parity, race/ethnicity and age, obese pregnant women were 3·0 (95 % CI 1·1, 7·7) times more likely to be in the lowest tertile of the EFA pattern and 4·5 (95 % CI 1·7, 12·3) times more likely to be in the lowest tertile of the Carotenoid pattern compared with their lean counterparts. We found no association between pre-pregnancy obesity and the Micronutrient pattern after confounder adjustment. Conclusions Our results suggest that obese pregnant women have diminished EFA and carotenoid concentrations.

Original languageEnglish (US)
Pages (from-to)1414-1418
Number of pages5
JournalPublic Health Nutrition
Volume16
Issue number8
DOIs
StatePublished - Aug 2013

Keywords

  • Factor analysis
  • Keywords Nutrition
  • Obesity
  • Pregnancy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

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