TY - JOUR
T1 - Precise development of functional and anatomical columns in the neocortex
AU - Bureau, Ingrid
AU - Shepherd, Gordon M G
AU - Svoboda, Karel
PY - 2004/6/10
Y1 - 2004/6/10
N2 - Sensory cortex is ordered into columns, each tuned to a subset of peripheral stimuli. To identify the principles underlying the construction of columnar architecture, we monitored the development of circuits in the rat barrel cortex, using laser-scanning photostimulation analysis of synaptic connectivity, reconstructions of axonal arbors, and in vivo whole-cell recording. Circuits impinging onto layer 2/3 neurons from layers 4 and 2/3 developed in a monotonic, precise progression, with little evidence for transient hyperinnervation at the level of cortical columns. Consistent with this, synaptic currents measured in layer 2/3 neurons at PND 8, just after these neurons ceased to migrate, revealed already spatially well-tuned receptive fields.
AB - Sensory cortex is ordered into columns, each tuned to a subset of peripheral stimuli. To identify the principles underlying the construction of columnar architecture, we monitored the development of circuits in the rat barrel cortex, using laser-scanning photostimulation analysis of synaptic connectivity, reconstructions of axonal arbors, and in vivo whole-cell recording. Circuits impinging onto layer 2/3 neurons from layers 4 and 2/3 developed in a monotonic, precise progression, with little evidence for transient hyperinnervation at the level of cortical columns. Consistent with this, synaptic currents measured in layer 2/3 neurons at PND 8, just after these neurons ceased to migrate, revealed already spatially well-tuned receptive fields.
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U2 - 10.1016/j.neuron.2004.05.002
DO - 10.1016/j.neuron.2004.05.002
M3 - Article
C2 - 15182718
AN - SCOPUS:2942553870
VL - 42
SP - 789
EP - 801
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 5
ER -