Precision medicine: Clarity for the complexity of dementia

Brenna Cholerton; Eric B. Larson; Joseph F. Quinn; Cyrus P. Zabetian; Ignacio F. Mata; C. Dirk Keene; Margaret Flanagan; Paul K. Crane; Thomas J. Grabowski; Kathleen S. Montine; Thomas J. Montine

doi:10.1016/j.ajpath.2015.12.001

Precision medicine: Clarity for the complexity of dementia

Brenna Cholerton, Eric B. Larson, Joseph F. Quinn, Cyrus P. Zabetian, Ignacio F. Mata, C. Dirk Keene, Margaret Flanagan, Paul K. Crane, Thomas J. Grabowski, Kathleen S. Montine, Thomas J. Montine^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.

Original language	English (US)
Pages (from-to)	500-506
Number of pages	7
Journal	American Journal of Pathology
Volume	186
Issue number	3
DOIs	https://doi.org/10.1016/j.ajpath.2015.12.001
State	Published - Mar 1 2016

Funding

Supported by NIH grants P50 AG005136 (T.J.M., C.D.K., T.J.G.), P50 NS062684 (T.J.M., C.P.Z., J.F.Q., T.J.G.), R01 AG042437 (P.K.C.), R01 NS065070 (C.P.Z.), and U01 AG006781 (E.B.L.); the Office of Research and Development Medical Research Service, Department of Veterans Affairs (C.P.Z., J.F.Q.); and the Nancy and Buster Alvord Endowment (T.J.M.).

ASJC Scopus subject areas

Pathology and Forensic Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ajpath.2015.12.001

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abstract = "Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.",

author = "Brenna Cholerton and Larson, {Eric B.} and Quinn, {Joseph F.} and Zabetian, {Cyrus P.} and Mata, {Ignacio F.} and Keene, {C. Dirk} and Margaret Flanagan and Crane, {Paul K.} and Grabowski, {Thomas J.} and Montine, {Kathleen S.} and Montine, {Thomas J.}",

note = "Funding Information: Supported by NIH grants P50 AG005136 (T.J.M., C.D.K., T.J.G.), P50 NS062684 (T.J.M., C.P.Z., J.F.Q., T.J.G.), R01 AG042437 (P.K.C.), R01 NS065070 (C.P.Z.), and U01 AG006781 (E.B.L.); the Office of Research and Development Medical Research Service, Department of Veterans Affairs (C.P.Z., J.F.Q.); and the Nancy and Buster Alvord Endowment (T.J.M.). Publisher Copyright: {\textcopyright} Copyright 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.",

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AU - Quinn, Joseph F.

AU - Zabetian, Cyrus P.

AU - Mata, Ignacio F.

AU - Keene, C. Dirk

AU - Flanagan, Margaret

AU - Crane, Paul K.

AU - Grabowski, Thomas J.

AU - Montine, Kathleen S.

AU - Montine, Thomas J.

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N2 - Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.

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Precision medicine: Clarity for the complexity of dementia

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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