Precision Medicine for Heart Failure with Preserved Ejection Fraction: An Overview

Sanjiv J. Shah*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


There are few proven therapies for heart failure with preserved ejection fraction (HFpEF). The lack of therapies, along with increased recognition of the disorder and its underlying pathophysiology, has led to the acknowledgement that HFpEF is heterogeneous and is not likely to respond to a one-size-fits-all approach. Thus, HFpEF is a prime candidate to benefit from a precision medicine approach. For this reason, we have assembled a compendium of papers on the topic of precision medicine in HFpEF in the Journal of Cardiovascular Translational Research. These papers cover a variety of topics relevant to precision medicine in HFpEF, including automated identification of HFpEF patients; machine learning, novel molecular approaches, genomics, and deep phenotyping of HFpEF; and clinical trial designs that can be used to advance precision medicine in HFpEF. In this introductory article, we provide an overview of precision medicine in HFpEF with the hope that the work described here and in the other papers in this special theme issue will stimulate investigators and clinicians to advance a more targeted approach to HFpEF classification and treatment.

Original languageEnglish (US)
Pages (from-to)233-244
Number of pages12
JournalJournal of Cardiovascular Translational Research
Issue number3
StatePublished - Jun 1 2017


  • Cluster analysis
  • Heart failure with preserved ejection fraction
  • Machine learning
  • Precision medicine
  • Treatment

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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