Precision medicine in chronic disease management: The multiple sclerosis BioScreen

Pierre Antoine Gourraud, Roland G. Henry, Bruce A.C. Cree, Jason C. Crane, Antoine Lizee, Marram P. Olson, Adam V. Santaniello, Esha Datta, Alyssa H. Zhu, Carolyn J. Bevan, Jeffrey M. Gelfand, Jennifer S. Graves, Douglas S. Goodin, Ari J. Green, H. Christian Von Büdingen, Emmanuelle Waubant, Scott S. Zamvil, Elizabeth Crabtree-Hartman, Sarah Nelson, Sergio E. BaranziniStephen L. Hauser*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


We present a precision medicine application developed for multiple sclerosis (MS): the MS BioScreen. This new tool addresses the challenges of dynamic management of a complex chronic disease; the interaction of clinicians and patients with such a tool illustrates the extent to which translational digital medicine - that is, the application of information technology to medicine - has the potential to radically transform medical practice. We introduce 3 key evolutionary phases in displaying data to health care providers, patients, and researchers: visualization (accessing data), contextualization (understanding the data), and actionable interpretation (real-time use of the data to assist decision making). Together, these form the stepping stones that are expected to accelerate standardization of data across platforms, promote evidence-based medicine, support shared decision making, and ultimately lead to improved outcomes.

Original languageEnglish (US)
Pages (from-to)633-642
Number of pages10
JournalAnnals of neurology
Issue number5
StatePublished - Nov 1 2014

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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