Precision Medicine in Pediatric Neurooncology: A Review

Aaron Y. Mochizuki, Isaura M. Frost, Melina B. Mastrodimos, Ashley S. Plant, Anthony C. Wang, Theodore B. Moore, Robert M. Prins, Paul S. Weiss*, Steven J. Jonas

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Central nervous system tumors are the leading cause of cancer related death in children. Despite much progress in the field of pediatric neurooncology, modern combination treatment regimens often result in significant late effects, such as neurocognitive deficits, endocrine dysfunction, secondary malignancies, and a host of other chronic health problems. Precision medicine strategies applied to pediatric neurooncology target specific characteristics of individual patients' tumors to achieve maximal killing of neoplastic cells while minimizing unwanted adverse effects. Here, we review emerging trends and the current literature that have guided the development of new molecularly based classification schemas, promising diagnostic techniques, targeted therapies, and delivery platforms for the treatment of pediatric central nervous system tumors.

Original languageEnglish (US)
Pages (from-to)11-28
Number of pages18
JournalACS Chemical Neuroscience
Volume9
Issue number1
DOIs
StatePublished - Jan 17 2018
Externally publishedYes

Keywords

  • Precision medicine
  • neurooncology
  • pediatrics
  • review

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cognitive Neuroscience
  • Cell Biology

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